Where to buy Epithalon Peptide: sizes, price per mg and how to verify the lot

What "epithalon peptide" names, and what it does not

Epithalon is four residues long, Ala-Glu-Asp-Gly, written AEDG in one-letter code; formula C14H22N4O9, average mass 390.4 Da, PubChem CID 219042. It came out of the St Petersburg peptide programme associated with Vladimir Khavinson, and the review cited at the foot of this page summarises that literature. The spelling is unsettled and listings write Epithalon, Epitalon, Epithalone and AEDG; those are one molecule. It is one of the smallest peptides in the catalogue and one of the most acidic, with two carboxylic acid side chains and a free C-terminus.

Small and acidic sets the buying problems. A tetrapeptide is cheap to make and its impurities are the tripeptides missing one residue (AED, EDG, ADG at 275, 319 and 261 Da), which are close enough on a reversed-phase column that only a laboratory reporting the main-peak mass has really identified the lot. The three acid groups mean the peptide holds counter-ion tightly, so a trifluoroacetate salt from purification can be a quarter of the powder by weight and the net content line decides what the labelled milligrams mean.

Vendor copy for this compound routinely goes well past what the sources it cites say; the published record is concentrated in one research tradition and thin outside it, and this page makes no claim about what the peptide does. It describes the material: a defined sequence, an exact mass, a known set of deletion impurities, and a salt form that has to be stated.

The reference point for identity is public. PubChem lists Epitalon as CID 219042 with molecular formula C14H22N4O9, an average molecular weight of 390.35 Da and a monoisotopic mass of 390.139 Da. Those are the numbers a mass spectrometer is checked against, and the number a certificate must print beside the observed mass.

In plain terms: A man-made peptide of four building blocks. No approved product, no official standard, and no settled mechanism. Claims made for this compound in vendor copy routinely go well past what the sources they cite actually say.

Epithalon for sale: sizes and price per mg

LabFirst lists Epithalon in 2 sizes (10mg, 50mg) from $40 to $109, priced per vial with the per-mg figure beside it so sizes can be compared without arithmetic. Per mg, the 50mg vial is the cheapest at $2.18 and the 10mg the dearest at $4, which is the usual shape: the vial, stopper, seal, fill and laboratory run cost the same whatever mass goes in.

The volume tiers are per size, not per basket: ten vials of one size take 10% off that line and twenty take 15%, and mixed sizes do not combine. Shipping is a flat $15 on orders under $200 and free from $200, within the United States only, with same-day dispatch on orders placed before 12 PM Pacific on a business day. The cost per mg tool runs the same comparison across any two listings, ours or anyone else's.

A four-residue synthesis of ordinary amino acids is among the cheapest work a peptide factory does, and Epithalon is priced accordingly, with the vial, the fill and the laboratory run making up most of the cost. That is why LabFirst lists 10 mg and 50 mg vials rather than single-digit sizes, and why the per-milligram figure falls so steeply between them. A laboratory that will use the material buys the 50 mg vial; one qualifying a lot buys the 10 mg vial once and reads the salt form and net content on its certificate.

The price signal is the salt. Two 10 mg listings at different prices may be the same peptide with different counter-ions and different peptide content, and the cheaper vial is not cheaper if it holds less peptide. Compare per milligram of peptide from the net content line, not per milligram of powder. The only discounts on this page are the volume tiers, per size and unchanged month to month, and the lot on the vial is whatever the certificate index says on the day.

The certificate a Epithalon lot must carry

Three tests answer three different questions, and a certificate of analysis for Epithalon is only complete when it carries all three for the exact lot on the vial. Identity is settled by mass spectrometry, and the number to look for on a Epithalon certificate is 390.139 Da monoisotopic (or 390.35 Da average, if the laboratory reports the deconvoluted average mass). The observed mass should sit within the instrument's stated tolerance of that figure, and the certificate should print both the theoretical and the observed value, not just a tick.

Purity is a separate question, answered by HPLC: how much of what came off the column was the compound. The figure is only interpretable with its method beside it (column, gradient, detection wavelength) and a date, which is what ICH Q2(R2) means when it asks that an analytical procedure be shown fit for its purpose. A percentage with no method and no date is a number somebody typed, and a certificate that carries every test but for a different lot number than the vial is the most common failure of all and the easiest to catch. Net content is the third test and the one most often missing: the milligrams of Epithalon actually in the vial, measured, against the size printed on the label.

Identity is the observed mass against 390.139 Da monoisotopic (390.4 Da average), seen in electrospray as m/z 391.1 for the singly charged ion in positive mode or 389.1 in negative mode, which suits an acidic peptide better. The deletion sequences to rule out are at 275, 319 and 261 Da; a certificate that prints the theoretical and observed mass and shows one main peak has ruled them out, and one that reads "identity: conforms" with no number has not. Because the mass is low, a good laboratory reports it to two decimal places, which is enough to separate AEDG from any other tetrapeptide of similar composition.

Purity by HPLC on a short acidic peptide needs a method chosen for it, since AEDG elutes early and can co-elute with its deletion products on a generic gradient; the chromatogram with its column, gradient and wavelength is the evidence. Net content is the line that pays on this compound: with three acid groups the peptide carries counter-ion generously, and a trifluoroacetate salt can leave a 10 mg label holding 7 or 8 mg of peptide. Quantitative HPLC against a standard, or amino acid analysis, tells you what the milligrams are made of, and the salt belongs beside that figure.

Where to buy Epithalon: five checks before you order from anyone

Every seller of epithalon peptide says "third-party tested". The phrase costs nothing. These five checks take about four minutes per listing and separate a tested lot from a tested-sounding one.

1. The lot on the vial is the lot on the certificate. Read the printed lot number, then open the certificate and match it. A certificate for "Epithalon" with no lot, or a lot that does not match, describes some other vial.
2. The laboratory is named and has its own lookup. The report should come from a laboratory the seller does not own, with a search code you can enter on the laboratory's own site. LabFirst lots are tested by Freedom Diagnostics and looked up by accession number; anything that can only be verified on the seller's own page has not been verified.
3. The theoretical mass is printed, and it is the right one. For Epithalon that is 390.139 Da monoisotopic; a certificate that prints a different figure has either measured a different molecule or copied a template.
4. Purity has a method and a date. An HPLC percentage should name the method and the run date. A figure that reads "99%+" with neither, or one date reused across every product a seller lists, is decoration.
5. Net content is stated in milligrams. The label size is a claim; the certificate's net content is the measurement. If the certificate has no net content line, the purity figure describes the powder, not the vial, and the price per mg you calculated is fiction.

How listings for Epithalon specifically mislead:

• "Epitalon 99.9%" with no mass. The deletion tripeptides run close to the main peak on a generic gradient; a purity number with no observed mass cannot show the main peak was AEDG.
• A 10 mg label with no salt form and no net content. Three acid groups hold counter-ion tightly; a trifluoroacetate lot can be a quarter salt by weight, and the milligrams of peptide are unknown without the content line.
• Copy that credits the tetrapeptide with results from a single research tradition as settled fact. The published record is concentrated and thin; a certificate describes the vial, not the copy.
• "Pharmaceutical grade Epithalon". There is no USP monograph and no approved product; the FDA placed Epitalon in Category 2 of its 503A list in September 2023, so no pharmacy may compound it.

How to verify a LabFirst Epithalon lot

The Epithalon sizes in stock today carry lots LF-2608-10 and PO-1001-ET50. Lot LF-2608-10 is at Freedom Diagnostics on accession FD-2026-05716 for identity, purity and net content. Until the report is attached the product page says "pending verification" against that lot and makes no purity claim; the price stands and the report goes live the day it arrives, on the page, at /coa/, and inside the receipt and packing slip for every order of that lot.

Verification runs through the laboratory, not through us. Open the certificate index, find the lot, and use the accession number on the Freedom Diagnostics lookup page; the report you see there is the laboratory's copy, not ours. Each lot also carries a Finnrick verify link, and every receipt and packing slip states that a customer may submit a sealed vial to Finnrick's free testing programme with the order as proof of purchase, so the brand's public record is built from vials we did not choose.

The product page reads the live stock feed on load (stock, lot and certificate state for every size), so what you see when you order is what ships. The lot is printed on the label and encoded in the QR patch on its right-hand side; scanning it opens that lot's record.

Storage and shipping for Epithalon

Epithalon has nothing in it that oxidises, no disulfide to scramble and no asparagine or glutamine to deamidate, so lyophilised and sealed at 2 to 8 C out of light it keeps for the full shelf period on the certificate. Its weakness is the same as every acidic peptide salt: it draws water from humid air once opened, and a cake that has absorbed moisture no longer weighs what the label says, so a vial is opened once, for its purpose, and never re-sealed for storage. In solution the aspartate side chain can slowly form a cyclic imide and rearrange, a reaction that depends on pH and temperature, so a prepared solution is dated, kept cold and used inside the laboratory's own stability record rather than any figure a label could carry.

Orders ship within the United States, flat $15 under $200 and free above it, same day when placed before 12 PM Pacific on a business day, and the shipping page states the cutoff, the carriers and what is and is not promised.

The record a laboratory keeps on arrival is what makes the certificate usable later, and it is short:

• the lot number as printed on the vial, and the certificate's accession or search code beside it;
• the date received and the condition of the seal;
• the storage location and temperature it went into;
• the number of vials, and later the date each one was opened and by whom.

A Epithalon vial with that record behind it can be traced from the bench to the laboratory report in one step; without it, the certificate is a document about a vial that can no longer be identified.

Regulatory status, and what this page is not

No approved medicine contains Epithalon and no USP or Ph. Eur. monograph defines an acceptable lot. In September 2023 the FDA placed Epitalon in Category 2 of its interim list of bulk drug substances nominated for compounding under section 503A, the category for substances it has identified as raising significant safety risks, which bars licensed pharmacies from compounding with it. That listing concerns pharmacies, not laboratory material, and is quoted because "pharmacy grade" appears in listings for a substance no pharmacy may currently compound.

FOR LABORATORY AND IN-VITRO RESEARCH USE ONLY. NOT FOR HUMAN OR ANIMAL CONSUMPTION. LabFirst sells Epithalon to laboratories and researchers as material for in-vitro work, gives no guidance on use, and ships only against that understanding. Nothing on this page or on the product page describes preparing or administering anything.

What is Epithalon studied for?

Published research on Epithalon investigates the areas below — which is a different question from what Epithalon will do for anyone, a claim about a living system that nothing on this site is sold for.

What it is. A man-made peptide of four building blocks.

What the research looks at. It appears in a limited set of animal and cell studies. The evidence behind it is far thinner than the volume of commercial writing about it suggests.

How it is thought to work. Not established. The published record is small, and much of the original work comes from a narrow group of researchers, which is a real limit when reading it.

What is not established. No approved product, no official standard, and no settled mechanism. Claims made for this compound in vendor copy routinely go well past what the sources they cite actually say.

The full record, including the certificate for the lot in stock, is on the Epithalon product page.

Common questions

Sources

• PubChem, Epitalon, CID 219042. Public record for the molecular formula (C14H22N4O9), average molecular weight (390.35 Da) and monoisotopic mass (390.139 Da) quoted here as the identity reference.
• Overview of Epitalon, a highly bioactive pineal tetrapeptide with promising properties 2025. Primary description of the compound in the literature; supports the class and naming stated here, not any use.
• Alliance for Pharmacy Compounding, 503A Categories Update, 29 September 2023 2023-09-29. Lists the substances the FDA moved to Category 2 on that date, including Epitalon.
• ICH Q2(R2), Validation of Analytical Procedures (2023) 2023-11. Why a purity figure is only interpretable with its method, and what "fit for purpose" means for the HPLC and mass spectrometry results a certificate reports.
• Freedom Diagnostics, certificate lookup by accession number. The laboratory-side lookup a LabFirst lot is verified on; the report there is the laboratory copy, not ours.
• Finnrick, verify a vendor or lot. Independent verification page linked from every LabFirst lot; customers may submit sealed vials with their order as proof of purchase.