TB-500 is a man-made peptide matching a section of thymosin beta-4 (formula C38H68N10O14, average mass 889 g/mol, CAS 885340-08-9). TB-500 is sold here for laboratory research in 2 sizes (5mg to 10mg), from $54.00 a vial. It is not an FDA-approved medicine. Research use only, and never for people or animals.
TB-500 specifications
| Product name | TB-500 |
|---|---|
| Also sold as | TB500, Thymosin beta-4 fragment, TB-500 peptide, thymosin b4 acetate |
| Formula | C38H68N10O14 |
| Average mass | 889 g/mol |
| CAS number | 885340-08-9 |
| Physical form | Freeze-dried powder, a solid cake in a sealed vial |
| Appearance | White to off-white cake |
| Sizes on this page | 5mg · 10mg |
| Purity specification | ≥99% by RP-HPLC. The number for the lot you receive is whatever its own certificate says. |
| Identity check | Mass spectrometry, read against the mass this compound should have |
| Net content | Weighed per lot and reported separately from purity |
| Lot documentation | Lot numbers assigned for 2 of 2 sizes; each lot's certificate posts here when Kovera Labs reports it |
| Storage | Sealed, cold and out of the light |
| Ships from | Santa Ana, California by USPS with tracking on every order, same business day on verified in-stock orders placed before 12 PM Pacific |
| Intended use | Laboratory research only. Not for human or animal use. |
What is TB-500, and what is it used for?
TB-500 is a man-made peptide matching one section of a natural protein called thymosin beta-4. It is sold as laboratory material.
TB-500 is also listed and searched as TB500, Thymosin beta-4 fragment, TB-500 peptide, thymosin b4 acetate. They all mean the same compound. Supplier lists write it as TB-500 peptides or peptide TB-500 as well; every one of those is this record. A name is not a test, which is why the lot record further down counts for more than the wording on a label.
Chemically: molecular formula C38H68N10O14, average mass 889 g/mol (PubChem CID 62707662). Those figures are what the identity test on a certificate is read against.
A man-made peptide matching a section of thymosin beta-4.
Thymosin beta-4 is a protein that grabs hold of actin, the building material of a cell’s internal skeleton, and the section sold as TB-500 is its actin-grabbing part. The published work is about how actin behaves and how cells move in culture.
Animal and cell-culture research on the cell skeleton and how cells move. Suppliers often blur TB-500 and full thymosin beta-4 together. They are not the same molecule, and this record is about the section.
No approved product, no official standard, and very little human research. The section-versus-whole-protein distinction gets blurred commercially, so check which one a certificate actually names.
TB-500 for sale: 5mg and 10mg vials, price per mg
TB-500 is sold in 2 sizes here, 5mg and 10mg, from $54.00 a vial. TB-500 cost and TB-500 price per mg by size are in the table, at each volume tier and on subscription; the per-mg figure under each price is the one that compares across sizes.
Volume and subscription pricing by size
| Size | One vial | 10–19 vials−10% | 20 vials−15% | Subscribe monthly−6% from shipment 2 | Availability |
|---|---|---|---|---|---|
| TB-500 5mg | $54.00$10.80/mg | $48.60a vial · $9.72/mg | $45.90a vial · $9.18/mg | $50.76a vial, shipment 2 on · $10.15/mg | Backordered — waitlist |
| TB-500 10mg | $60.00$6.00/mg | $54.00a vial · $5.40/mg | $51.00a vial · $5.10/mg | $56.40a vial, shipment 2 on · $5.64/mg | Backordered — waitlist |
Volume tiers are per size and do not combine across sizes (see bulk pricing). Subscribe & Save takes 6% every month, 4% every 2 months or 2% every 3 months off from shipment 2, two shipments minimum, and stacks on the volume tier: the lowest this record ever bills is $8.63 per mg, twenty 5mg vials on a monthly subscription from shipment 2 onward.
Nothing is added at checkout except the USPS shipping you choose; dispatch and delivery are the same on every order. The cost-per-milligram tool ranks the whole catalog by price per mg. The certificate walked through field by field: Where to Buy TB-500 Peptide: Five Checks Before You Order.
Where to buy TB-500: what to check before you order from anyone
Where to get TB-500, and how to buy TB-500 online
TB-500 for sale, or TB-500 peptide for sale, means this page: one record, 2 sizes. You can buy TB-500 online here with guest checkout, and purchase TB-500 or order TB-500 in any size below; verified in-stock orders placed before 12 PM Pacific are dispatched the same day.
Before ordering TB-500 from anyone, us included, run the 5 checks on verifying a certificate; the first is that the report resolves on the laboratory's own site, and a seller who cannot pass them is asking for the trust a certificate exists to replace.
TB-500 reviews
No customer review of TB-500 has been published yet, so there is no star rating here; when real ones exist the number will be the arithmetic of what people wrote. Ordered this record? Leave a review. A person reads every one before it appears.
TB-500 capsules, oral form or nasal spray? What this vial is, and is not
Search results for TB-500 also show capsules, oral form, nasal spray products, under listing titles such as tb 500 capsules, tb 500 oral, tb 500 nasal spray, tb 500 pills, oral tb 500, tb 500 spray. Those are finished consumer goods made and marketed by other companies, and none of them is what this page sells. This record is freeze-dried TB-500 in a sealed glass vial, 5mg and 10mg, with a lot certificate, supplied for laboratory work. Its certificate describes that powder, not a capsule, spray or cream, which carry other ingredients and sit under different rules.
TB-500 guides and documentation
Written to answer the questions that come up around TB-500 specifically, what its paperwork should show, how it is handled, and how to judge a supplier selling it.
- BPC-157 TB-500 blend: the two peptides in one vial, sizes and ratios
- Glow peptide: what is in a GLOW vial, and why the ratio lives on the certificate
- GLOW certificates of analysis: how to read a report on three peptides at once
- How GLOW identity gets confirmed when one sample holds three peptides
- KLOW peptide: four peptides in one vial, and why the name is not a specification
- KLOW certificate of analysis: reading a report on four peptides at once
The full library, grouped by what you came to answer, is in the laboratory guides.
The TB-500 certificate: lot, purity, identity, and how to verify it
A certificate answers identity, purity and net content as three separate questions, each with the method that produced it and the date it was run, how to read one covers what each field does and does not cover. For TB-500 that means a mass spectrum landing on 889 g/mol for C38H68N10O14, the figure published against PubChem CID 62707662. The cataloged form is TB-500, and the identity test resolves to that rather than to a related molecule with a similar name.
TB-500 certificates post here and in the certificate index when Kovera Labs reports on the lot.
Solution arithmetic for the bench, with no administration guidance: the vial concentration calculator, preset to TB-500.
Where the FDA stands on TB-500
FDA status, and what this listing is Not an FDA-approved drug product
The FDA has not approved this compound for anything, and nothing in this catalog is a medicine.
Status verified 2026-08-25. Check the primary source before relying on this summary.
It is sold as laboratory material under the research-use restriction below. Being listed is not an approval, and not a claim that it is safe, effective or right for any purpose.
TB-500 research: what the published studies examine
Status: No FDA-approved application. This compound is sold as laboratory material. Where research on it has been published, it sits at the animal, cell or early-human stage, and this record does not summarize what it found. A supplier is not a neutral judge of evidence about its own catalog.
TB-500 is a piece of thymosin beta-4, so the thymosin beta-4 research is where its mechanism comes from. That protein grabs single actin units one at a time and holds them out of play, which stops actin filaments growing and shifts the balance between loose actin and built-up actin. Crystal images showed how it does it: a short section called the WH2 motif caps both ends of an actin unit, and the hand-off between thymosin beta-4 and another protein, profilin, works because their grip sites overlap slightly.
Since building actin is what moves a cell, anything that changes how much free actin is available changes how cells move, and that is the thread running through the tissue-repair studies.
| Reported observation | Model | Source |
|---|---|---|
| The thymosin beta-4 and actin pairing was imaged by X-ray crystallography down to 2 Å. Thymosin beta-4 holds an actin unit by capping both of its ends, and the WH2 motif was identified as the actin-grabbing part, shared with other proteins that either hold actin back or help build filaments. | X-ray crystallography of the purified complex | Irobi, Aguda, Larsson, Guerin, Yin, Burtnick, Blanchoin and Robinson, Structural basis of actin sequestration by thymosin-β4, EMBO Journal 23(18):3599-3608 (2004) |
| A structural account of how thymosin beta-4 hands actin over to profilin so filament building can start again, describing how a held-back actin unit rejoins the pool that builds filaments. | structural and biochemical analysis | Structural basis of thymosin-β4/profilin exchange leading to actin filament polymerization, PNAS (2014) |
| Mapping of where thymosin beta-4 grips actin, by competing it against other actin-binding proteins. Grips on opposite sides of the actin unit turned out to interfere with one another. | competition binding assay | Mapping the binding site of thymosin β4 on actin by competition with G-actin binding proteins, European Journal of Biochemistry (1998) |
Open questions. The structural biology is settled; the applied research is not. Tissue-repair studies use the whole thymosin beta-4 protein as often as the short section sold as TB-500, and a result for one cannot be read as a result for the other. No completed human efficacy trial of the section has been published. Where a second route (integrin-linked kinase and Akt) is described alongside the actin story, it is a proposal rather than an established fact.
Each row above describes an observation in the stated model. None of it describes what TB-500 would do in a person or an animal outside that model, and none of it is a recommendation to use it for anything.
How to store TB-500: refrigeration and shelf life
Keep the sealed vial cold and out of the light and it stays as it left the lab. Once it is mixed into a solution, how long it holds up depends on the compound, what it was mixed with, how strong the solution is and how cold it is kept — too many variables for anyone to print one shelf life on a label. So laboratories write the date on whatever they prepare and keep their own record of it.
For solution preparation arithmetic on the bench, concentration, per-graduation values and molarity, use the vial concentration calculator, which opens with the TB-500 sizes stocked here already loaded. It covers laboratory measurement only and contains no administration guidance.
