Where to buy DSIP Peptide: sizes, price per mg and how to verify the lot

What "dsip peptide" names, and what it does not

DSIP is a nine-residue synthetic peptide, Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, written WAGGDASGE; formula C35H48N10O15, average mass 848.8 Da, PubChem CID 68816. The 1977 paper cited at the foot of this page reported it from rabbit blood and named it for an electroencephalogram observation, and the 2006 review cited beside it is titled, accurately, a still unresolved riddle: no receptor has been identified and the mechanism was never settled. Its nonproprietary name is emideltide, which is how the FDA lists it. Listings write DSIP, DSIP peptide and delta sleep-inducing peptide; one molecule.

The name describes an early observation, not a demonstrated mechanism, and the most useful thing a buyer can know about DSIP is that the research is thin and old; this page makes no claim about what the peptide does. What it can say precisely is what the peptide is: a short, acidic sequence with one tryptophan, two acid side chains and a free C-terminus, cheap to make, and easy to get wrong in three specific ways that a certificate can show.

The three ways are a missing glycine (there are three, and a deletion runs close to the main peak), an oxidised tryptophan (the indole ring picks up oxygen on light exposure, adding 16 or 32 Da), and the salt. With two acids and a free terminus the peptide holds counter-ion tightly, and a trifluoroacetate lot can be a fifth salt by weight, so the net content line decides what a labelled milligram means.

The reference point for identity is public. PubChem lists Delta sleep-inducing peptide as CID 68816 with molecular formula C35H48N10O15, an average molecular weight of 848.8 Da and a monoisotopic mass of 848.33 Da. Those are the numbers a mass spectrometer is checked against, and the number a certificate must print beside the observed mass.

In plain terms: Delta sleep-inducing peptide, a man-made peptide nine building blocks long. No approved product, no confirmed receptor, and a name that describes an early observation rather than a demonstrated mechanism. The research is thin and old, and that is the most important thing to know about it.

DSIP for sale: sizes and price per mg

LabFirst lists DSIP in 2 sizes (5mg, 10mg) from $49 to $54, priced per vial with the per-mg figure beside it so sizes can be compared without arithmetic. Per mg, the 10mg vial is the cheapest at $5.40 and the 5mg the dearest at $9.80, which is the usual shape: the vial, stopper, seal, fill and laboratory run cost the same whatever mass goes in.

The volume tiers are per size, not per basket: ten vials of one size take 10% off that line and twenty take 15%, and mixed sizes do not combine. Shipping is a flat $15 on orders under $200 and free from $200, within the United States only, with same-day dispatch on orders placed before 12 PM Pacific on a business day. The cost per mg tool runs the same comparison across any two listings, ours or anyone else's.

Nine ordinary residues make DSIP a cheap synthesis, and the price of a vial is mostly the vial, the fill and the laboratory work, which is why the 10 mg vial costs only a little more than the 5 mg and the per-milligram figure nearly halves between them. A laboratory that will use the material buys the 10 mg vial; one qualifying a lot buys the 5 mg vial once and reads the salt form, the mass and the oxidation peaks on its certificate.

The price signal is the salt and the light. A lot that was purified with trifluoroacetic acid and never exchanged to acetate holds less peptide per milligram, and a lot stored in daylight carries oxidised tryptophan; both get discounted. Compare per milligram of peptide from the net content line, not per milligram of powder. The only discounts on this page are the volume tiers, per size and unchanged month to month, and the lot on the vial is whatever the certificate index says on the day.

The certificate a DSIP lot must carry

Three tests answer three different questions, and a certificate of analysis for DSIP is only complete when it carries all three for the exact lot on the vial. Identity is settled by mass spectrometry, and the number to look for on a DSIP certificate is 848.33 Da monoisotopic (or 848.8 Da average, if the laboratory reports the deconvoluted average mass). The observed mass should sit within the instrument's stated tolerance of that figure, and the certificate should print both the theoretical and the observed value, not just a tick.

Purity is a separate question, answered by HPLC: how much of what came off the column was the compound. The figure is only interpretable with its method beside it (column, gradient, detection wavelength) and a date, which is what ICH Q2(R2) means when it asks that an analytical procedure be shown fit for its purpose. A percentage with no method and no date is a number somebody typed, and a certificate that carries every test but for a different lot number than the vial is the most common failure of all and the easiest to catch. Net content is the third test and the one most often missing: the milligrams of DSIP actually in the vial, measured, against the size printed on the label.

Identity is the observed mass against 848.330 Da monoisotopic (848.8 Da average), seen in electrospray as m/z 849.3 for the singly charged ion or 847.3 in negative mode, which suits an acidic peptide; the certificate should print theoretical and observed. A mass 57 Da low is a missing glycine, a common deletion in a sequence with three of them; peaks at +16 and +32 Da are oxidised tryptophan, honest at a fraction of a percent and a warning as a main peak. A certificate reading "conforms" with no number has not distinguished DSIP from its own deletion product.

Purity by HPLC should show the chromatogram with its column, gradient and wavelength, since the des-glycine deletion elutes near the parent on a generic method and the oxidised forms elute earlier; the tryptophan gives DSIP a strong absorbance at 280 nm, which is a convenient second wavelength for confirming the main peak is the tryptophan-containing molecule. Net content is the line that pays on a small acidic peptide: quantitative HPLC against a standard or amino acid analysis tells you how many of the labelled milligrams are peptide rather than trifluoroacetate or acetate and water, and the salt belongs beside that figure.

Where to buy DSIP: five checks before you order from anyone

Every seller of dsip peptide says "third-party tested". The phrase costs nothing. These five checks take about four minutes per listing and separate a tested lot from a tested-sounding one.

1. The lot on the vial is the lot on the certificate. Read the printed lot number, then open the certificate and match it. A certificate for "DSIP" with no lot, or a lot that does not match, describes some other vial.
2. The laboratory is named and has its own lookup. The report should come from a laboratory the seller does not own, with a search code you can enter on the laboratory's own site. LabFirst lots are tested by Freedom Diagnostics and looked up by accession number; anything that can only be verified on the seller's own page has not been verified.
3. The theoretical mass is printed, and it is the right one. For DSIP that is 848.33 Da monoisotopic; a certificate that prints a different figure has either measured a different molecule or copied a template.
4. Purity has a method and a date. An HPLC percentage should name the method and the run date. A figure that reads "99%+" with neither, or one date reused across every product a seller lists, is decoration.
5. Net content is stated in milligrams. The label size is a claim; the certificate's net content is the measurement. If the certificate has no net content line, the purity figure describes the powder, not the vial, and the price per mg you calculated is fiction.

How listings for DSIP specifically mislead:

• Copy that presents the name as a finding. DSIP was named for an observation in 1977, no receptor has been identified, and a certificate describes a vial, not a mechanism.
• "DSIP 99%" with no observed mass. Three glycines make a des-glycine deletion likely and it runs close to the parent; a purity number without the mass cannot show which peptide the main peak is.
• A 10 mg label with no salt form and no net content. Two acid side chains and a free terminus hold counter-ion tightly; a trifluoroacetate lot can be a fifth salt by weight.
• "Pharmaceutical grade DSIP". There is no USP monograph and no approved product; the FDA placed emideltide (DSIP) in Category 2 of its 503A list in September 2023, so no pharmacy may compound it.

How to verify a LabFirst DSIP lot

The DSIP sizes in stock today carry lot LF-2608-09. Lot LF-2608-09 is at Freedom Diagnostics on accession FD-2026-05716 for identity, purity and net content. Until the report is attached the product page says "pending verification" against that lot and makes no purity claim; the price stands and the report goes live the day it arrives, on the page, at /coa/, and inside the receipt and packing slip for every order of that lot.

Verification runs through the laboratory, not through us. Open the certificate index, find the lot, and use the accession number on the Freedom Diagnostics lookup page; the report you see there is the laboratory's copy, not ours. Each lot also carries a Finnrick verify link, and every receipt and packing slip states that a customer may submit a sealed vial to Finnrick's free testing programme with the order as proof of purchase, so the brand's public record is built from vials we did not choose.

The product page reads the live stock feed on load (stock, lot and certificate state for every size), so what you see when you order is what ships. The lot is printed on the label and encoded in the QR patch on its right-hand side; scanning it opens that lot's record.

Storage and shipping for DSIP

Tryptophan is the storage story. The indole ring oxidises on exposure to light and air, slowly in the sealed dry cake at 2 to 8 C in the dark and quickly in a solution left on a lit bench, so a prepared DSIP solution is kept cold and dark, dated, and used inside the laboratory's own stability record rather than any figure on a label. The aspartate at position 5 can slowly rearrange in solution through a cyclic imide, a reaction that depends on pH. The dry cake's other enemy is water drawn from humid air once the vial is opened, which an acidic peptide salt takes up readily; open a vial once, for its purpose, and never re-seal one for storage.

Orders ship within the United States, flat $15 under $200 and free above it, same day when placed before 12 PM Pacific on a business day, and the shipping page states the cutoff, the carriers and what is and is not promised.

The record a laboratory keeps on arrival is what makes the certificate usable later, and it is short:

• the lot number as printed on the vial, and the certificate's accession or search code beside it;
• the date received and the condition of the seal;
• the storage location and temperature it went into;
• the number of vials, and later the date each one was opened and by whom.

A DSIP vial with that record behind it can be traced from the bench to the laboratory report in one step; without it, the certificate is a document about a vial that can no longer be identified.

Regulatory status, and what this page is not

No approved medicine contains DSIP and no USP or Ph. Eur. monograph defines an acceptable lot. In September 2023 the FDA placed Emideltide (DSIP) in Category 2 of its interim list of bulk drug substances nominated for compounding under section 503A, the category for substances it has identified as raising significant safety risks, which bars licensed pharmacies from compounding with it. That listing concerns pharmacies, not laboratory material, and is quoted because "pharmacy grade" appears in listings for a substance no pharmacy may currently compound.

FOR LABORATORY AND IN-VITRO RESEARCH USE ONLY. NOT FOR HUMAN OR ANIMAL CONSUMPTION. LabFirst sells DSIP to laboratories and researchers as material for in-vitro work, gives no guidance on use, and ships only against that understanding. Nothing on this page or on the product page describes preparing or administering anything.

What is DSIP studied for?

Published research on DSIP investigates the areas below — which is a different question from what DSIP will do for anyone, a claim about a living system that nothing on this site is sold for.

What it is. Delta sleep-inducing peptide, a man-made peptide nine building blocks long.

What the research looks at. A small and largely historical body of animal work, much of it decades old.

How it is thought to work. Not established. The peptide was named for something noticed in early animal work, not for a receptor anyone has found, and no target has ever been confirmed.

What is not established. No approved product, no confirmed receptor, and a name that describes an early observation rather than a demonstrated mechanism. The research is thin and old, and that is the most important thing to know about it.

The full record, including the certificate for the lot in stock, is on the DSIP product page.

Common questions

Sources

• PubChem, Delta sleep-inducing peptide, CID 68816. Public record for the molecular formula (C35H48N10O15), average molecular weight (848.8 Da) and monoisotopic mass (848.33 Da) quoted here as the identity reference.
• Schoenenberger and Monnier, Characterization of a delta-electroencephalogram (-sleep)-inducing peptide, Proceedings of the National Academy of Sciences 1977. Primary description of the compound in the literature; supports the class and naming stated here, not any use.
• Kovalzon and Strekalova, Delta sleep-inducing peptide (DSIP): a still unresolved riddle, Journal of Neurochemistry 2006. Primary description of the compound in the literature; supports the class and naming stated here, not any use.
• Alliance for Pharmacy Compounding, 503A Categories Update, 29 September 2023 2023-09-29. Lists the substances the FDA moved to Category 2 on that date, including Emideltide (DSIP).
• ICH Q2(R2), Validation of Analytical Procedures (2023) 2023-11. Why a purity figure is only interpretable with its method, and what "fit for purpose" means for the HPLC and mass spectrometry results a certificate reports.
• Freedom Diagnostics, certificate lookup by accession number. The laboratory-side lookup a LabFirst lot is verified on; the report there is the laboratory copy, not ours.
• Finnrick, verify a vendor or lot. Independent verification page linked from every LabFirst lot; customers may submit sealed vials with their order as proof of purchase.