This page compares what is documented about MOTS-c (Human) and NAD+, rather than ranking them by effect. What each molecule is, the sizes and prices actually carried, what the certificate covers, and how the two differ on the bench. Everything here is research-use-only material and we do not publish outcome, dosing or administration content for any compound in the catalogue.
What is MOTS-c (Human) and what is NAD+?
MOTS-c (Human). MOTS-c is encoded inside the mitochondrial 12S rRNA gene — a mitochondrial-derived peptide studied in metabolic-signalling and exercise-biology models since 2015.
NAD+. NAD+ sits at the center of cellular-energetics and aging research; declining NAD+ pools are one of the most replicated observations in the geroscience literature.
How do MOTS-c (Human) and NAD+ compare on price and size?
| MOTS-c (Human) | NAD+ | |
|---|---|---|
| Sizes carried | 10 mg, 20 mg, 40 mg | 100 mg, 500 mg, 1000 mg |
| From | $60.00 | $40.00 |
| Best price per unit | $2.50 / mg | $0.11 / mg |
| Availability | Backordered — waitlist | Backordered — waitlist |
| Certificate | Lot certificate on the product page | Lot certificate on the product page |
| Molecular formula | C101H152N28O22S2 | C21H27N7O14P2 |
| Molar mass | 2,174.6 g/mol | 663.4 g/mol |
| Source | PubChem CID 146675088 | PubChem CID 5892 |
| Research area | mitochondrial-signalling research | NAD+ metabolism research |
At their best sizes NAD+ works out at $0.11 per mg against $2.50 for MOTS-c (Human) — 22.7 times more for the mg. Vial prices start at $60.00 and $40.00 respectively, which is the number most people compare and the one that says least, because the two are not sold in the same sizes. Full sizes, tier pricing and the lot certificate sit on the MOTS-c (Human) page and the NAD+ page.
What is each one studied for?
What the published literature investigates, which is a different question from what either will do, and the only one of the two a supplier can answer.
MOTS-c (Human) is studied in mitochondrial-signalling research. Mitochondrial-derived peptides are a young and fast-moving corner of metabolic research, with MOTS-c the most-studied of the family.
NAD+ is studied in nad+ metabolism research. NAD+ metabolism remains one of the most-published areas of geroscience, with sirtuin and PARP pathway work continuing to expand.
Studied in the same area does not make two compounds interchangeable, and the research library holds the per-compound documentation.
NAD+ vs Mots C: how they differ on the bench
NAD+. NAD+ is hygroscopic and light-sensitive — the reason our labels say KEEP DARK and the guide says desiccate. A clumped vial has already told you its storage history.
MOTS-c (Human). MOTS-c is a 16-residue peptide with a critical central motif; sequence-level identity confirmation matters more here than for longer, more forgiving chains.
On naming, because the two are written several ways and the difference is not always obvious: MOTS-c (Human) is also written mots c. They refer to the same materials described here, and the certificate for a lot uses the name on this page. The comparison itself is usually typed Mots C vs NAD+.
What actually differs between NAD+ and MOTS-c (Human)
Worth doing the arithmetic before comparing sizes: MOTS-c (Human) is 2,174.6 g/mol and NAD+ is 663.4 g/mol, a factor of 3.3. A milligram of NAD+ therefore contains roughly 3.3 times as many molecules as a milligram of MOTS-c (Human), so two vials of the same labelled mass hold quite different amounts of substance. Equal milligrams are not equal moles, which is what the molarity calculator exists to convert, and it is the reason a price-per-milligram comparison and a price-per-mole comparison can point at different vials.
Identity is the other analytical axis, and it is settled per lot rather than per compound. MOTS-c (Human). Catalogued as MOTS-c, and the certificate's identity test resolves to that. NAD+. Catalogued as NAD+ (nicotinamide adenine dinucleotide), and the certificate's identity test resolves to that.
Both are released against a certificate reporting identity, purity by the stated method and net peptide content, readable before anything is bought.
Which is better, NAD+ or Mots C?
Neither NAD+ nor Mots C is ranked against the other here, and the refusal is deliberate. Better, safer and stronger are questions about effects in a living system, and we sell neither compound for use in one — why none of these pages ranks two compounds sets out the reasoning in full.
What it does instead, for these two:
- NAD+ is the cheaper of the two per mg, at $0.11 against $2.50.
- MOTS-c (Human) is the heavier molecule by a factor of 3.3, so equal milligrams are not equal moles.
- Both are carried in 3 sizes, and each lot carries its own certificate.
Every one of those is checkable before you buy.
Common questions
What is the difference between NAD+ and MOTS-c (Human)?
Different molecules before anything else: NAD+ is C21H27N7O14P2 and MOTS-c (Human) is C101H152N28O22S2. NAD+ sits at the center of cellular-energetics and aging research; declining NAD+ pools are one of the most replicated observations in the geroscience literature. MOTS-c is encoded inside the mitochondrial 12S rRNA gene — a mitochondrial-derived peptide studied in metabolic-signalling and exercise-biology models since 2015.
Which one should I choose?
MOTS-c (Human) is carried in 10 mg, 20 mg, 40 mg and NAD+ in 100 mg, 500 mg, 1000 mg, each lot with its own certificate. Which of those suits the work is yours to decide; everything here is research-use-only rather than guidance for use in a human or an animal.
Do both MOTS-c (Human) and NAD+ come with a certificate of analysis?
Neither is in stock at the moment, so in each case the certificate is the one attached to the lot that arrives. A certificate belongs to a lot, not to a product. It is linked from the product page, and reports identity, purity by the stated method, and net peptide content for the material actually in that lot.
Which is cheaper, NAD+ or MOTS-c (Human)?
Per mg, NAD+ at $0.11 against $2.50, taking each one's best size. By vial they start at $60.00 for MOTS-c (Human) and $40.00 for NAD+, which is the comparison most people make and the one that says least, because the two are not sold in the same sizes.
Is a milligram of MOTS-c (Human) the same as a milligram of NAD+?
By mass yes, by amount of substance no. MOTS-c (Human) is 2,174.6 g/mol and NAD+ is 663.4 g/mol, a factor of 3.3, so a milligram of NAD+ holds roughly 3.3 times as many molecules. Two vials with the same number on the label are not the same amount of substance, which is what the molarity calculator converts.
FOR LABORATORY AND IN-VITRO RESEARCH USE ONLY. NOT FOR HUMAN OR ANIMAL CONSUMPTION. NOT FOR PERSONAL, MEDICAL, DIAGNOSTIC, THERAPEUTIC, OR RECREATIONAL USE.