This page compares what is documented about AOD9604 and MOTS-c (Human), rather than ranking them by effect. What each molecule is, the sizes and prices actually carried, what the certificate covers, and how the two differ on the bench. Everything here is research-use-only material and we do not publish outcome, dosing or administration content for any compound in the catalogue.
What is AOD9604 and what is MOTS-c (Human)?
AOD9604. AOD9604 is the C-terminal hGH(177-191) fragment with a disulfide loop — studied in lipolysis models precisely because it strips away the rest of the hormone's activity.
MOTS-c (Human). MOTS-c is encoded inside the mitochondrial 12S rRNA gene — a mitochondrial-derived peptide studied in metabolic-signalling and exercise-biology models since 2015.
How do AOD9604 and MOTS-c (Human) compare on price and size?
| AOD9604 | MOTS-c (Human) | |
|---|---|---|
| Sizes carried | 5 mg, 10 mg | 10 mg, 20 mg, 40 mg |
| From | $44.00 | $60.00 |
| Best price per unit | $7.50 / mg | $2.50 / mg |
| Availability | Backordered — waitlist | Backordered — waitlist |
| Certificate | Lot certificate on the product page | Lot certificate on the product page |
| Molecular formula | C78H123N23O23S2 | C101H152N28O22S2 |
| Molar mass | 1,815.1 g/mol | 2,174.6 g/mol |
| Source | PubChem CID 71300630 | PubChem CID 146675088 |
| Research area | lipolysis-model research | mitochondrial-signalling research |
At their best sizes MOTS-c (Human) works out at $2.50 per mg against $7.50 for AOD9604 — 3.0 times more for the mg. Vial prices start at $44.00 and $60.00 respectively, which is the number most people compare and the one that says least, because the two are not sold in the same sizes. Full sizes, tier pricing and the lot certificate sit on the AOD9604 page and the MOTS-c (Human) page.
What is each one studied for?
What the published literature investigates, which is a different question from what either will do, and the only one of the two a supplier can answer.
AOD9604 is studied in lipolysis-model research. Fragment-based hormone research continues to use AOD9604 as the canonical example of isolating one activity from a parent hormone.
MOTS-c (Human) is studied in mitochondrial-signalling research. Mitochondrial-derived peptides are a young and fast-moving corner of metabolic research, with MOTS-c the most-studied of the family.
Studied in the same area does not make two compounds interchangeable, and the research library holds the per-compound documentation.
Mots-c vs AOD 9604: how they differ on the bench
MOTS-c (Human). MOTS-c is a 16-residue peptide with a critical central motif; sequence-level identity confirmation matters more here than for longer, more forgiving chains.
AOD9604. The disulfide bridge is the fragile part: reducing conditions break AOD9604 into something else entirely. Storage dry and dark protects it.
On naming, because the two are written several ways and the difference is not always obvious: AOD9604 is also written aod 9604; MOTS-c (Human) is also written mots-c. They refer to the same materials described here, and the certificate for a lot uses the name on this page. The comparison itself is usually typed AOD 9604 vs Mots-c.
What actually differs between MOTS-c (Human) and AOD9604
Worth doing the arithmetic before comparing sizes: MOTS-c (Human) is 2,174.6 g/mol and AOD9604 is 1,815.1 g/mol, a factor of 1.2. A milligram of AOD9604 therefore contains roughly 1.2 times as many molecules as a milligram of MOTS-c (Human), so two vials of the same labelled mass hold quite different amounts of substance. Equal milligrams are not equal moles, which is what the molarity calculator exists to convert, and it is the reason a price-per-milligram comparison and a price-per-mole comparison can point at different vials.
Identity is the other analytical axis, and it is settled per lot rather than per compound. AOD9604. Catalogued as AOD-9604, and the certificate's identity test resolves to that. MOTS-c (Human). Catalogued as MOTS-c, and the certificate's identity test resolves to that.
Both are released against a certificate reporting identity, purity by the stated method and net peptide content, readable before anything is bought.
Which is better, Mots-c or AOD 9604?
Neither Mots-c nor AOD 9604 is ranked against the other here, and the refusal is deliberate. Better, safer and stronger are questions about effects in a living system, and we sell neither compound for use in one — why none of these pages ranks two compounds sets out the reasoning in full.
What it does instead, for these two:
- MOTS-c (Human) is the cheaper of the two per mg, at $2.50 against $7.50.
- MOTS-c (Human) is the heavier molecule by a factor of 1.2, so equal milligrams are not equal moles.
- AOD9604 is carried in 2 sizes and MOTS-c (Human) in 3, and each lot carries its own certificate.
Every one of those is checkable before you buy.
Common questions
What is the difference between MOTS-c (Human) and AOD9604?
Different molecules before anything else: MOTS-c (Human) is C101H152N28O22S2 and AOD9604 is C78H123N23O23S2. MOTS-c is encoded inside the mitochondrial 12S rRNA gene — a mitochondrial-derived peptide studied in metabolic-signalling and exercise-biology models since 2015. AOD9604 is the C-terminal hGH(177-191) fragment with a disulfide loop — studied in lipolysis models precisely because it strips away the rest of the hormone's activity.
Which one should I choose?
AOD9604 is carried in 5 mg, 10 mg and MOTS-c (Human) in 10 mg, 20 mg, 40 mg, each lot with its own certificate. Which of those suits the work is yours to decide; everything here is research-use-only rather than guidance for use in a human or an animal.
Do both AOD9604 and MOTS-c (Human) come with a certificate of analysis?
Neither is in stock at the moment, so in each case the certificate is the one attached to the lot that arrives. A certificate belongs to a lot, not to a product. It is linked from the product page, and reports identity, purity by the stated method, and net peptide content for the material actually in that lot.
Which is cheaper, MOTS-c (Human) or AOD9604?
Per mg, MOTS-c (Human) at $2.50 against $7.50, taking each one's best size. By vial they start at $44.00 for AOD9604 and $60.00 for MOTS-c (Human), which is the comparison most people make and the one that says least, because the two are not sold in the same sizes.
Is a milligram of AOD9604 the same as a milligram of MOTS-c (Human)?
By mass yes, by amount of substance no. MOTS-c (Human) is 2,174.6 g/mol and AOD9604 is 1,815.1 g/mol, a factor of 1.2, so a milligram of AOD9604 holds roughly 1.2 times as many molecules. Two vials with the same number on the label are not the same amount of substance, which is what the molarity calculator converts.
FOR LABORATORY AND IN-VITRO RESEARCH USE ONLY. NOT FOR HUMAN OR ANIMAL CONSUMPTION. NOT FOR PERSONAL, MEDICAL, DIAGNOSTIC, THERAPEUTIC, OR RECREATIONAL USE.