MOTS-c is a 16-building-block peptide whose recipe is written in mitochondrial DNA (formula C101H152N28O22S2, average mass 2,174.6 g/mol, CAS 1627580-64-6). MOTS-c (Human) is sold here for laboratory research in 3 sizes (10mg to 40mg), from $60.00 a vial. It is not an FDA-approved medicine. Research use only, and never for people or animals.
MOTS-c specifications
| Product name | MOTS-c (Human) |
|---|---|
| Also sold as | MOTS-c (Human), MOTS-c peptide, MOT-C peptide, MOTS-c human sequence |
| Formula | C101H152N28O22S2 |
| Average mass | 2,174.6 g/mol |
| CAS number | 1627580-64-6 |
| Physical form | Freeze-dried powder, a solid cake in a sealed vial |
| Appearance | White to off-white cake |
| Sizes on this page | 10mg · 20mg · 40mg |
| Purity specification | ≥99% by RP-HPLC. The number for the lot you receive is whatever its own certificate says. |
| Identity check | Mass spectrometry, read against the mass this compound should have |
| Net content | Weighed per lot and reported separately from purity |
| Lot documentation | 2 of 3 sizes have a published Kovera Labs certificate (10mg, lot LF-18A-2609; 40mg, lot LF-18C-2609); the other 1 is in testing |
| Storage | Sealed, cold and out of the light |
| Ships from | Santa Ana, California by USPS with tracking on every order, same business day on verified in-stock orders placed before 12 PM Pacific |
| Intended use | Laboratory research only. Not for human or animal use. |
What is MOTS-c, and what is it used for?
MOTS-c is a short peptide whose recipe is stored in the mitochondria, the parts of a cell that make its energy. It is sold as laboratory material.
MOTS-c is also listed and searched as MOTS-c (Human), MOTS-c peptide, MOT-C peptide, MOTS-c human sequence, MOTSc, mitochondrial open reading frame peptide. They all mean the same compound. Supplier lists write it as MOTS-c peptides or peptide MOTS-c as well; every one of those is this record. A name is not a test, which is why the lot record further down counts for more than the wording on a label.
Chemically: molecular formula C101H152N28O22S2, average mass 2174.6 g/mol (PubChem CID 146675088). Those figures are what the identity test on a certificate is read against.
A 16-building-block peptide whose recipe is written in mitochondrial DNA.
Described in the research as a mitochondrial peptide involved in metabolic signalling. The details are still being worked out and the published models are not settled.
A relatively recent basic-science record on mitochondrial peptides and metabolic signalling, mostly in cells and animals.
No approved product and no official standard. The field is young enough that the explanations change between papers, so a claim resting on a single study should be read as provisional.
MOTS-c for sale: 10mg, 20mg and 40mg vials, price per mg
MOTS-c is sold in 3 sizes here, 10mg, 20mg and 40mg, from $60.00 a vial. MOTS-c cost and MOTS-c price per mg by size are in the table, at each volume tier and on subscription; the per-mg figure under each price is the one that compares across sizes.
Volume and subscription pricing by size
| Size | One vial | 10–19 vials−10% | 20 vials−15% | Subscribe monthly−6% from shipment 2 | Availability |
|---|---|---|---|---|---|
| MOTS-c 10mg | $60.00$6.00/mg | $54.00a vial · $5.40/mg | $51.00a vial · $5.10/mg | $56.40a vial, shipment 2 on · $5.64/mg | In stock |
| MOTS-c 20mg | $75.00$3.75/mg | $67.50a vial · $3.38/mg | $63.75a vial · $3.19/mg | $70.50a vial, shipment 2 on · $3.52/mg | Backordered — waitlist |
| MOTS-c 40mgBest per mg | $100.00$2.50/mg | $90.00a vial · $2.25/mg | $85.00a vial · $2.13/mg | $94.00a vial, shipment 2 on · $2.35/mg | In stock |
The 40mg vial works out 58% cheaper per mg than the 10mg. Volume tiers are per size and do not combine across sizes (see bulk pricing). Subscribe & Save takes 6% every month, 4% every 2 months or 2% every 3 months off from shipment 2, two shipments minimum, and stacks on the volume tier: the lowest this record ever bills is $2.00 per mg, twenty 40mg vials on a monthly subscription from shipment 2 onward.
Nothing is added at checkout except the USPS shipping you choose; dispatch and delivery are the same on every order. The cost-per-milligram tool ranks the whole catalog by price per mg. The certificate walked through field by field: Where to Buy MOTS-c Peptide: Five Checks Before You Order.
Where to buy MOTS-c: what to check before you order from anyone
Where to get MOTS-c, and how to buy MOTS-c online
MOTS-c for sale, or MOTS-c peptide for sale, means this page: one record, 3 sizes. You can buy MOTS-c online here with guest checkout, and purchase MOTS-c or order MOTS-c in any size below; verified in-stock orders placed before 12 PM Pacific are dispatched the same day. If the question is where to get MOTS-c or how to get MOTS-c, the answer for a US laboratory is a supplier who publishes the certificate before you pay, which is the first of the five checks that follow.
Before ordering MOTS-c from anyone, us included, run the 5 checks on verifying a certificate; the first is that the report resolves on the laboratory's own site, and a seller who cannot pass them is asking for the trust a certificate exists to replace.
MOTS-c (Human) reviews
No customer review of MOTS-c (Human) has been published yet, so there is no star rating here; when real ones exist the number will be the arithmetic of what people wrote. Ordered this record? Leave a review. A person reads every one before it appears.
MOTS-c capsules or oral form? What this vial is, and is not
Search results for MOTS-c also show capsules, oral form products, under listing titles such as mots-c oral, mots-c tablets, mots-c peptide oral, mots-c peptide pill form, mots c capsules, mots c peptide capsules. Those are finished consumer goods made and marketed by other companies, and none of them is what this page sells. This record is freeze-dried MOTS-c in a sealed glass vial, 10mg, 20mg and 40mg, with a lot certificate, supplied for laboratory work. Its certificate describes that powder, not a capsule, spray or cream, which carry other ingredients and sit under different rules.
MOTS-c vs NAD+ and Semaglutide: different molecules, separate records
MOTS-c vs NAD+, or NAD+ vs MOTS-c, is the comparison people search most, with Semaglutide close behind, and they are not the same thing. Each is a different molecule with a different formula, mass and research record, and each has its own certificate here.
NAD+ vs MOTS-c: the same comparison, side by side
| Record | Class | Formula | Avg. mass | Sizes here |
|---|---|---|---|---|
| MOTS-c (Human) | A 16-building-block peptide whose recipe is written in mitochondrial DNA. | C101H152N28O22S2 | 2174.6 | 10mg · 20mg · 40mg from $60.00 |
| NAD+ | Nicotinamide adenine dinucleotide, a helper molecule rather than a peptide. | C21H27N7O14P2 | 663.4 | 100mg · 500mg · 1000mg from $40.00 |
| Semaglutide | A peptide that works on the GLP-1 receptor. | C187H291N45O59 | 4114 | 5mg · 10mg · 15mg · 20mg · 30mg from $55.00 |
Documentation compared in full: MOTS-c vs NAD+, side by side · MOTS-c vs Semaglutide, side by side.
MOTS-c guides and documentation
Written to answer the questions that come up around MOTS-c specifically, what its paperwork should show, how it is handled, and how to judge a supplier selling it.
- MOTS-c (Human) certificates of analysis, field by field, and how to check one at the lab
- MOTS-c (Human) Identity Testing: How It Is Confirmed
- MOTS-c Human Storage and Stability in the Laboratory
The full library, grouped by what you came to answer, is in the laboratory guides.
The MOTS-c certificate: lot, purity, identity, and how to verify it
A certificate answers identity, purity and net content as three separate questions, each with the method that produced it and the date it was run, how to read one covers what each field does and does not cover. For MOTS-c that means a mass spectrum landing on 2,174.6 g/mol for C101H152N28O22S2, the figure published against PubChem CID 146675088. The cataloged form is MOTS-c, and the identity test resolves to that rather than to a related molecule with a similar name.
| Size | Lot | Identity method | Purity | Endotoxin · sterility · fentanyl | Test date |
|---|---|---|---|---|---|
| 10mg | LF-18A-2609 | LC-MS | 99.786% (RP-HPLC, C18, DAD @ 214 nm) | 2026-09-29 | |
| 40mg | LF-18C-2609 | LC-MS | 99.422% (RP-HPLC, C18, DAD @ 214 nm) | 2026-09-29 |
Testing by Kovera Labs. Every batch tested on or after October 1, 2026 includes endotoxin, sterility and fentanyl screening, in addition to identity, purity and net content. Open the report, then confirm it on the issuing laboratory's own site. If the identifier does not resolve there, or resolves to a different lot than the one printed on your vial, the document is worthless however convincing it looks.
- Certificate for lot LF-18A-2609 · Report PDF · Verify at Kovera Labs
- Certificate for lot LF-18C-2609 · Report PDF · Verify at Kovera Labs
The lot number on the certificate must match the lot printed on the vial you received. That match is the only thing tying the document to your material. Net content is reported separately from purity, because a vial can be highly pure and still hold less material than its label states.
Where the FDA stands on MOTS-c
FDA status, and what this listing is Not an FDA-approved drug product
The FDA has not approved this compound for anything, and nothing in this catalog is a medicine.
Status verified 2026-08-25. Check the primary source before relying on this summary.
It is sold as laboratory material under the research-use restriction below. Being listed is not an approval, and not a claim that it is safe, effective or right for any purpose.
MOTS-c research: what the published studies examine
Status: No FDA-approved application. This compound is sold as laboratory material. Where research on it has been published, it sits at the animal, cell or early-human stage, and this record does not summarize what it found. A supplier is not a neutral judge of evidence about its own catalog.
MOTS-c is a 16-building-block peptide whose instructions sit inside a mitochondrial gene, which is what makes it structurally unusual: the recipe lives in mitochondrial DNA rather than in the cell nucleus. The mechanism described in the founding work is indirect and specific. MOTS-c blocks the folate cycle and the purine building attached to it, a molecule called AICAR piles up as a result, and AICAR is itself a natural switch for AMPK, one of the cell’s main energy sensors.
So the route runs folate cycle to AICAR to AMPK, not direct binding to the sensor. Later work reports the peptide moving into the nucleus when the cell is under metabolic stress and acting on gene activity there, which is unusual for something encoded in mitochondria.
| Reported observation | Model | Source |
|---|---|---|
| The paper that identified MOTS-c and the folate-AICAR-AMPK route. In mice on a high-fat diet, injected man-made MOTS-c prevented the diet-driven weight gain and insulin resistance seen in untreated animals. Blocking AMPK partly wiped out the effect, which is the evidence that AMPK is a required step rather than a bystander. | mouse, high-fat diet, intraperitoneal administration | Lee and colleagues, The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance, Cell Metabolism (2015) |
| MOTS-c moves into the nucleus when a cell is under metabolic stress and acts on gene activity there, describing signalling that runs from the mitochondria back to the nucleus. | cell culture under metabolic stress | Kim and colleagues, The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression, Cell Metabolism (2018) |
| A review of the folate-AICAR-AMPK route and the reported links to energy use, insulin resistance, inflammation and ageing. | review of the published literature | Mitochondria-derived peptide MOTS-c: effects and mechanisms related to stress, metabolism and aging, Journal of Translational Medicine (2023) |
Open questions. The metabolic work is in rodents. Human data is mostly observed association between MOTS-c levels in blood and metabolic measures, not treatment. The founding result is a prevention experiment: mice got the peptide alongside a high-fat diet from the start, which is a different question from reversing something already established, and the two get run together constantly when this compound is described.
Each row above describes an observation in the stated model. None of it describes what MOTS-c (Human) would do in a person or an animal outside that model, and none of it is a recommendation to use it for anything.
How to store MOTS-c: refrigeration and shelf life
Keep the sealed vial cold and out of the light and it stays as it left the lab. Once it is mixed into a solution, how long it holds up depends on the compound, what it was mixed with, how strong the solution is and how cold it is kept — too many variables for anyone to print one shelf life on a label. So laboratories write the date on whatever they prepare and keep their own record of it.
For solution preparation arithmetic on the bench, concentration, per-graduation values and molarity, use the vial concentration calculator, which opens with the MOTS-c (Human) sizes stocked here already loaded. It covers laboratory measurement only and contains no administration guidance.
