Matrixyl is palmitoyl pentapeptide-4, palmitoyl-Lys-Thr-Thr-Lys-Ser (pal-KTTKS) — a lipidated fragment of type I procollagen (formula C39H75N7O10, average mass 802.1 g/mol, CAS 214047-00-4). Matrixyl is sold here for laboratory research in 1 size (10mg), from $55.00 a vial. It is not an FDA-approved medicine. Research use only, and never for people or animals.
Matrixyl specifications
| Product name | Matrixyl |
|---|---|
| Also sold as | palmitoyl pentapeptide-4, Matrixyl peptide |
| Formula | C39H75N7O10 |
| Average mass | 802.1 g/mol |
| CAS number | 214047-00-4 |
| Physical form | Freeze-dried powder, a solid cake in a sealed vial |
| Appearance | White to off-white cake |
| Sizes on this page | 10mg |
| Purity specification | ≥99% by RP-HPLC. The number for the lot you receive is whatever its own certificate says. |
| Identity check | Mass spectrometry, read against the mass this compound should have |
| Net content | Weighed per lot and reported separately from purity |
| Lot documentation | Tested by Kovera Labs; each lot's certificate posts here when it is reported |
| Storage | Sealed, cold and out of the light |
| Ships from | Santa Ana, California by USPS with tracking on every order, same business day on verified in-stock orders placed before 12 PM Pacific |
| Regulatory status | Not an FDA-approved drug product. Sold as laboratory material, not a medicine; status verified 2026-08-25. |
| Intended use | Laboratory research only. Not for human or animal use. |
What is Matrixyl, and what is it used for?
Matrixyl is also listed and searched as palmitoyl pentapeptide-4, Matrixyl peptide. They all mean the same compound. Supplier lists write it as Matrixyl peptides or peptide Matrixyl as well; every one of those is this record. A name is not a test, which is why the lot record further down counts for more than the wording on a label.
Chemically: molecular formula C39H75N7O10, average mass 802.1 g/mol (PubChem CID 9897237). Those figures are what the identity test on a certificate is read against.
Palmitoyl pentapeptide-4, palmitoyl-Lys-Thr-Thr-Lys-Ser (pal-KTTKS) — a lipidated fragment of type I procollagen.
KTTKS is a subfragment of the C-terminal propeptide of type I collagen, proposed to act as a feedback signal stimulating collagen synthesis. The palmitoyl group is added to make an otherwise hydrophilic pentapeptide able to cross the stratum corneum.
Topical cosmetic use on photoaged facial skin. One of very few compounds on this catalog with a published randomised placebo-controlled human trial of the actual marketed form.
Mechanism at the molecular level. The collagen-feedback hypothesis is plausible and has not been demonstrated as the operative pathway in human skin.
Matrixyl for sale: 10mg vials, price per mg
Matrixyl is sold in 1 size here, 10mg, from $55.00 a vial. Every way of buying is in the table; the per-mg figure under each price is the one that compares across sizes.
Volume and subscription pricing by size
| Size | One vial | 10–19 vials−10% | 20 vials−15% | Subscribe monthly−6% from shipment 2 | Availability |
|---|---|---|---|---|---|
| Matrixyl 10mg | $55.00$5.50/mg | $49.50a vial · $4.95/mg | $46.75a vial · $4.67/mg | $51.70a vial, shipment 2 on · $5.17/mg | Backordered — waitlist |
Volume tiers are per size and do not combine across sizes (see bulk pricing). Subscribe & Save takes 6% every month, 4% every 2 months or 2% every 3 months off from shipment 2, two shipments minimum, and stacks on the volume tier: the lowest this record ever bills is $4.39 per mg, twenty 10mg vials on a monthly subscription from shipment 2 onward.
Nothing is added at checkout except the USPS shipping you choose; dispatch and delivery are the same on every order. The cost-per-milligram tool ranks the whole catalog by price per mg.
Where to buy Matrixyl: what to check before you order from anyone
You can buy Matrixyl online here with guest checkout; verified in-stock orders placed before 12 PM Pacific are dispatched the same day.
Before ordering Matrixyl from anyone, us included, run the 5 checks on verifying a certificate; the first is that the report resolves on the laboratory's own site, and a seller who cannot pass them is asking for the trust a certificate exists to replace.
Matrixyl reviews
No customer review of Matrixyl has been published yet, so there is no star rating here; when real ones exist the number will be the arithmetic of what people wrote. Ordered this record? Leave a review. A person reads every one before it appears.
Matrixyl cream or serum? What this vial is, and is not
Search results for Matrixyl also show cream or serum products, under listing titles such as matrixyl 3000 serum, matrixyl peptide serum, best matrixyl serum, matrixyl serum, best matrixyl 3000 serum, matrixyl 3000 peptide serum. Those are finished consumer goods made and marketed by other companies, and none of them is what this page sells. This record is freeze-dried Matrixyl in a sealed glass vial, 10mg, with a lot certificate, supplied for laboratory work. Its certificate describes that powder, not a capsule, spray or cream, which carry other ingredients and sit under different rules.
Matrixyl guides and documentation
Written to answer the questions that come up around Matrixyl specifically, what its paperwork should show, how it is handled, and how to judge a supplier selling it.
- Matrixyl Certificate of Analysis, read line by line for pal-KTTKS
- Matrixyl storage and stability for the sealed vial and lab solutions
- Palmitoyl Pentapeptide-4: Structure, Nomenclature and Measurement
The full library, grouped by what you came to answer, is in the laboratory guides.
The Matrixyl certificate: lot, purity, identity, and how to verify it
A certificate answers identity, purity and net content as three separate questions, each with the method that produced it and the date it was run, how to read one covers what each field does and does not cover. For Matrixyl that means a mass spectrum landing on 802.1 g/mol for C39H75N7O10, the figure published against PubChem CID 9897237.
Matrixyl certificates post here and in the certificate index when Kovera Labs reports on the lot.
Solution arithmetic for the bench, with no administration guidance: the vial concentration calculator, preset to Matrixyl.
Matrixyl research: what the published studies examine
Status: No FDA-approved application. This compound is sold as laboratory material. Where research on it has been published, it sits at the animal, cell or early-human stage, and this record does not summarize what it found. A supplier is not a neutral judge of evidence about its own catalog.
Matrixyl is palmitoyl-KTTKS, and both halves of that name are doing work. KTTKS is a naturally occurring subfragment of the C-terminal propeptide of type I collagen — the piece cleaved off during collagen maturation — and the hypothesis behind the compound is that this fragment acts as a feedback signal telling fibroblasts to make more collagen. The palmitoyl group is a delivery solution rather than an active feature: a small hydrophilic pentapeptide will not cross the stratum corneum, and attaching a fatty acid makes it lipophilic enough to penetrate.
What distinguishes this compound on this catalog is that it was tested as the finished product in a properly designed human trial, at the concentration actually used commercially, with an appropriate control. That is rare here, and it is worth noting that the concentration in question is very low.
| Reported observation | Model | Source |
|---|---|---|
| A 12-week double-blind, placebo-controlled, split-face, left-right randomised study in 93 Caucasian women aged 35 to 55 compared a moisturiser control against the same moisturiser containing 3 ppm pal-KTTKS. Pal-KTTKS was well tolerated and provided significant improvement against placebo control for reduction in wrinkles and fine lines by both quantitative technical and expert-grader image analysis, with subjects also reporting significant improvements in self-assessment. | 12-week double-blind placebo-controlled split-face randomised trial, 93 participants | Robinson and colleagues, Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin, International Journal of Cosmetic Science (2005)Authored at Procter and Gamble, who market products containing it. The split-face design is genuinely good — each participant serves as her own control. |
Open questions. The trial design here is the best on this catalog for a topical: split-face means each participant is her own control, it was double-blind and placebo-controlled with both instrumented and expert-graded outcomes, and it tested the commercial concentration rather than an idealised one. Three caveats. It was conducted and authored by the company that markets products containing the ingredient, which does not invalidate a split-face design but is worth knowing.
The effective concentration was 3 parts per million, which is very low, and more is not established as better — for a signalling fragment, dose-response is not assumed monotonic. And the mechanism remains a hypothesis: the collagen-propeptide feedback story is plausible and the human evidence is about visible outcome rather than about collagen synthesis being the pathway. Note finally that this is a topical cosmetic ingredient by design, and the palmitoylation exists specifically to solve skin penetration — a property with no relevance to any other route.
Each row above describes an observation in the stated model. None of it describes what Matrixyl would do in a person or an animal outside that model, and none of it is a recommendation to use it for anything.
How to store Matrixyl: refrigeration and shelf life
Keep the sealed vial cold and out of the light and it stays as it left the lab. Once it is mixed into a solution, how long it holds up depends on the compound, what it was mixed with, how strong the solution is and how cold it is kept — too many variables for anyone to print one shelf life on a label. So laboratories write the date on whatever they prepare and keep their own record of it.
For solution preparation arithmetic on the bench, concentration, per-graduation values and molarity, use the vial concentration calculator, which opens with the Matrixyl sizes stocked here already loaded. It covers laboratory measurement only and contains no administration guidance.
