IGF-1 LR3 is analogue of human insulin-like growth factor 1 with arginine replacing glutamate at position 3 and a thirteen-residue N-terminal extension. IGF-1 LR3 is sold here for laboratory research in 2 sizes (0.1mg to 1mg), from $65.00 a vial. It is not an FDA-approved medicine. Research use only, and never for people or animals.
IGF-1 LR3 specifications
| Product name | IGF-1 LR3 |
|---|---|
| Also sold as | IGF-1 LR3 peptide, LR3-IGF-1, Long R3 IGF-1 |
| Physical form | Freeze-dried powder, a solid cake in a sealed vial |
| Appearance | White to off-white cake |
| Sizes on this page | 0.1mg · 1mg |
| Purity specification | ≥99% by RP-HPLC. The number for the lot you receive is whatever its own certificate says. |
| Identity check | Mass spectrometry, read against the mass this compound should have |
| Net content | Weighed per lot and reported separately from purity |
| Lot documentation | Tested by Kovera Labs; each lot's certificate posts here when it is reported |
| Storage | Sealed, cold and out of the light |
| Ships from | Santa Ana, California by USPS with tracking on every order, same business day on verified in-stock orders placed before 12 PM Pacific |
| Intended use | Laboratory research only. Not for human or animal use. |
What is IGF-1 LR3, and what is it used for?
IGF-1 LR3 is also listed and searched as IGF-1 LR3 peptide, LR3-IGF-1, Long R3 IGF-1. They all mean the same compound. Supplier lists write it as IGF-1 LR3 peptides or peptide IGF-1 LR3 as well; every one of those is this record. A name is not a test, which is why the lot record further down counts for more than the wording on a label.
Analogue of human insulin-like growth factor 1 with arginine replacing glutamate at position 3 and a thirteen-residue N-terminal extension.
Binds the IGF-1 receptor. The substitutions markedly reduce affinity for IGF binding proteins, which is the design intent: less sequestration by IGFBPs means more free peptide available to the receptor.
Used principally as a cell-culture reagent — it is a standard supplement in serum-free and reduced-serum media for industrial and research cell culture — and as a comparator in IGF analogue pharmacology.
No approved product and no human therapeutic data. Reduced IGFBP binding is a property demonstrated in binding assays; that it produces greater biological effect does not follow, and in at least one published comparison it did not.
IGF-1 LR3 for sale: 0.1mg and 1mg vials, price per mg
IGF-1 LR3 is sold in 2 sizes here, 0.1mg and 1mg, from $65.00 a vial. IGF-1 LR3 cost and IGF-1 LR3 price per mg by size are in the table, at each volume tier and on subscription; the per-mg figure under each price is the one that compares across sizes.
Volume and subscription pricing by size
| Size | One vial | 10–19 vials−10% | 20 vials−15% | Subscribe monthly−6% from shipment 2 | Availability |
|---|---|---|---|---|---|
| IGF-1 LR3 0.1mg | $65.00$650.00/mg | $58.50a vial · $585.00/mg | $55.25a vial · $552.50/mg | $61.10a vial, shipment 2 on · $611.00/mg | Backordered — waitlist |
| IGF-1 LR3 1mg | $95.00$95.00/mg | $85.50a vial · $85.50/mg | $80.75a vial · $80.75/mg | $89.30a vial, shipment 2 on · $89.30/mg | Backordered — waitlist |
Volume tiers are per size and do not combine across sizes (see bulk pricing). Subscribe & Save takes 6% every month, 4% every 2 months or 2% every 3 months off from shipment 2, two shipments minimum, and stacks on the volume tier: the lowest this record ever bills is $519.35 per mg, twenty 0.1mg vials on a monthly subscription from shipment 2 onward.
Nothing is added at checkout except the USPS shipping you choose; dispatch and delivery are the same on every order. The cost-per-milligram tool ranks the whole catalog by price per mg.
Where to buy IGF-1 LR3: what to check before you order from anyone
Where to get IGF-1 LR3, and how to buy IGF-1 LR3 online
IGF-1 LR3 for sale, or IGF-1 LR3 peptide for sale, means this page: one record, 2 sizes. You can buy IGF-1 LR3 online here with guest checkout; verified in-stock orders placed before 12 PM Pacific are dispatched the same day. A IGF-1 LR3 supplier, vendor or source worth using will show you the lot number and where its certificate can be verified.
Before ordering IGF-1 LR3 from anyone, us included, run the 5 checks on verifying a certificate; the first is that the report resolves on the laboratory's own site, and a seller who cannot pass them is asking for the trust a certificate exists to replace.
IGF-1 LR3 reviews
No customer review of IGF-1 LR3 has been published yet, so there is no star rating here; when real ones exist the number will be the arithmetic of what people wrote. Ordered this record? Leave a review. A person reads every one before it appears.
IGF-1 LR3 capsules, nasal spray or oral form? What this vial is, and is not
Search results for IGF-1 LR3 also show capsules, nasal spray, oral form products, under listing titles such as igf 1 lr3 nasal spray, igf 1 lr3 oral, igf 1 lr3 pills, hgh igf 1 lr3 powder, igf 1 lr3 pill form, igf 1 lr3 tablet. Those are finished consumer goods made and marketed by other companies, and none of them is what this page sells. This record is freeze-dried IGF-1 LR3 in a sealed glass vial, 0.1mg and 1mg, with a lot certificate, supplied for laboratory work. Its certificate describes that powder, not a capsule, spray or cream, which carry other ingredients and sit under different rules.
IGF-1 LR3 vs IGF-1 DES and CJC-1295 (no DAC): different molecules, separate records
IGF-1 LR3 vs IGF-1 DES, or IGF-1 DES vs IGF-1 LR3, is the comparison people search most, with CJC-1295 (no DAC) close behind, and they are not the same thing. Each is a different molecule with a different formula, mass and research record, and each has its own certificate here.
IGF-1 DES vs IGF-1 LR3: the same comparison, side by side
| Record | Class | Formula | Avg. mass | Sizes here |
|---|---|---|---|---|
| IGF-1 LR3 | Analogue of human insulin-like growth factor 1 with arginine replacing glutamate at position 3 and a thirteen-residue N-terminal extension. | — | — | 0.1mg · 1mg from $65.00 |
| IGF-1 DES | Analogue of human insulin-like growth factor 1 lacking the N-terminal tripeptide Gly-Pro-Glu. | — | — | 2mg from $75.00 |
| CJC-1295 (no DAC) | A man-made 29-building-block copy of GHRH, also sold under the name Mod GRF(1-29). | C152H252N44O42 | 3367.9 | 5mg · 10mg from $34.00 |
Documentation compared in full: IGF-1 LR3 vs IGF-1 DES, side by side · IGF-1 LR3 vs CJC-1295 (no DAC), side by side.
The IGF-1 LR3 certificate: lot, purity, identity, and how to verify it
A certificate answers identity, purity and net content as three separate questions, each with the method that produced it and the date it was run, how to read one covers what each field does and does not cover. IGF-1 LR3 is an ANALOGUE of IGF-1, not IGF-1 itself: an arginine substitution at position 3 plus a 13-residue N-terminal extension. UniProt P05019 is the parent protein for reference; the analogue has its own mass, which the lot certificate reports. So the mass on the lot certificate is the one to read; a listing that quotes the published figure for this material is quoting the wrong molecule.
IGF-1 LR3 certificates post here and in the certificate index when Kovera Labs reports on the lot.
Is IGF-1 LR3 legal? FDA status, and what this listing is
FDA status, and what this listing is Not an FDA-approved drug product
The FDA has not approved this compound for anything, and nothing in this catalog is a medicine.
Status verified 2026-08-25. Check the primary source before relying on this summary.
Whether IGF-1 LR3 is legal depends on what it is being used for and where. It is sold as laboratory material under the research-use restriction below. Being listed is not an approval, and not a claim that it is safe, effective or right for any purpose.
IGF-1 LR3 research: what the published studies examine
Status: No FDA-approved application. This compound is sold as laboratory material. Where research on it has been published, it sits at the animal, cell or early-human stage, and this record does not summarize what it found. A supplier is not a neutral judge of evidence about its own catalog.
Long R3 IGF-1 is human IGF-1 with arginine substituted for glutamate at position 3 and an N-terminal extension of thirteen residues, Met-Phe-Pro-Ala-Met-Pro-Leu-Ser-Ser-Leu-Phe-Val-Asn. Both changes exist to reduce binding to the IGF binding proteins, which in circulation sequester the great majority of IGF-1 and limit how much reaches the receptor. The reasoning is straightforward and the binding data support it.
What does not automatically follow is greater potency: in a published head-to-head comparison the analogue was less active than native IGF-1 in one assay and failed to reach significance in another where native IGF-1 and des(1-3)IGF-I both succeeded. Escaping the binding proteins changes distribution and clearance as well as availability, and those can work against each other.
| Reported observation | Model | Source |
|---|---|---|
| In a direct comparison at 12.5 micrograms per liter, IGF-I, des(1-3)IGF-I and long R3 IGF-I increased hydrogen peroxide release by bovine neutrophils by 65%, 64% and 32% respectively — the analogue designed to escape binding proteins was the LEAST active. At 100 micrograms per liter, IGF-I and des(1-3)IGF-I significantly stimulated thymidine incorporation into mononuclear cells but long R3 IGF-I did not. | bovine neutrophils and mononuclear cells, with binding assays against serum IGFBPs and IGF-1 receptors | Zhao, McBride, Trouten-Radford and Burton, Effects of insulin-like growth factor-I and its analogues on bovine hydrogen peroxide release by neutrophils and blastogenesis by mononuclear cells, Journal of Endocrinology (1993)A useful corrective: the analogue marketed as more potent was the weakest of the three in both assays here. |
Open questions. The structure is well defined and the reduced IGFBP affinity is real. The inference usually drawn from it — that this analogue is therefore more potent than IGF-1 — is not supported by the comparison above, where it was the least active of three in one assay and inactive in another. That is one paper in bovine cells and should not be over-read either, but it is the head-to-head data that exists and it points the opposite way to the marketing.
Beyond that: no human data, no approved product, and the compound's established role is as a cell-culture reagent, which is a legitimate research use and a different thing from a therapeutic candidate. IGF-1 receptor agonism is also mitogenic by nature, and the long-term consequences of unopposed signalling are the reason this axis is approached cautiously in drug development.
Each row above describes an observation in the stated model. None of it describes what IGF-1 LR3 would do in a person or an animal outside that model, and none of it is a recommendation to use it for anything.
How to store IGF-1 LR3: refrigeration and shelf life
Keep the sealed vial cold and out of the light and it stays as it left the lab. Once it is mixed into a solution, how long it holds up depends on the compound, what it was mixed with, how strong the solution is and how cold it is kept — too many variables for anyone to print one shelf life on a label. So laboratories write the date on whatever they prepare and keep their own record of it.
For solution preparation arithmetic on the bench, concentration, per-graduation values and molarity, use the vial concentration calculator, which opens with the IGF-1 LR3 sizes stocked here already loaded. It covers laboratory measurement only and contains no administration guidance.
