CJC-1295 with DAC is tetrasubstituted analogue of human GRF(1-29) bearing a maleimidopropionamide lysine — the Drug Affinity Complex — at the C-terminus (formula C165H269N47O46, average mass 3,647.2 g/mol, CAS 446262-90-4). CJC-1295 (with DAC) is sold here for laboratory research in 1 size (5mg), from $130.00 a vial. It is not an FDA-approved medicine. Research use only, and never for people or animals.
CJC-1295 with DAC specifications
| Product name | CJC-1295 (with DAC) |
|---|---|
| Also sold as | CJC-1295 DAC, CJC 1295 w/ DAC, CJC-1295 DAC peptide |
| Formula | C165H269N47O46 |
| Average mass | 3,647.2 g/mol |
| CAS number | 446262-90-4 |
| Physical form | Freeze-dried powder, a solid cake in a sealed vial |
| Appearance | White to off-white cake |
| Sizes on this page | 5mg |
| Purity specification | ≥99% by RP-HPLC. The number for the lot you receive is whatever its own certificate says. |
| Identity check | Mass spectrometry, read against the mass this compound should have |
| Net content | Weighed per lot and reported separately from purity |
| Lot documentation | Tested by Kovera Labs; each lot's certificate posts here when it is reported |
| Storage | Sealed, cold and out of the light |
| Ships from | Santa Ana, California by USPS with tracking on every order, same business day on verified in-stock orders placed before 12 PM Pacific |
| Regulatory status | Not an FDA-approved drug product. Sold as laboratory material, not a medicine; status verified 2026-08-25. |
| Intended use | Laboratory research only. Not for human or animal use. |
What is CJC-1295 with DAC?
CJC-1295 with DAC is also listed and searched as CJC-1295 DAC, CJC 1295 w/ DAC, CJC-1295 DAC peptide. They all mean the same compound. A name is not a test, which is why the lot record further down counts for more than the wording on a label.
Chemically: molecular formula C165H269N47O46, average mass 3647.2 g/mol (PubChem CID 91971820). Those figures are what the identity test on a certificate is read against.
Tetrasubstituted analogue of human GRF(1-29) bearing a maleimidopropionamide lysine — the Drug Affinity Complex — at the C-terminus.
Agonist at the GHRH receptor on pituitary somatotrophs. The maleimide group reacts covalently with the free thiol at Cys34 of circulating serum albumin, and that conjugation is what extends the half-life from minutes to days.
Characterized in rats, in GHRH knockout mice, and in two randomised placebo-controlled ascending-dose trials in healthy adults. Development did not continue to an approved product.
No approved product and no modern safety record. Sustained rather than pulsatile elevation of growth hormone and IGF-1 is a departure from the physiological pattern whose consequences are not established.
CJC-1295 with DAC for sale: 5mg vials, price per mg
CJC-1295 with DAC is sold in 1 size here, 5mg, from $130.00 a vial. Every way of buying is in the table; the per-mg figure under each price is the one that compares across sizes.
Volume and subscription pricing by size
| Size | One vial | 10–19 vials−10% | 20 vials−15% | Subscribe monthly−6% from shipment 2 | Availability |
|---|---|---|---|---|---|
| CJC-1295 with DAC 5mg | $130.00$26.00/mg | $117.00a vial · $23.40/mg | $110.50a vial · $22.10/mg | $122.20a vial, shipment 2 on · $24.44/mg | Backordered — waitlist |
Volume tiers are per size and do not combine across sizes (see bulk pricing). Subscribe & Save takes 6% every month, 4% every 2 months or 2% every 3 months off from shipment 2, two shipments minimum, and stacks on the volume tier: the lowest this record ever bills is $20.77 per mg, twenty 5mg vials on a monthly subscription from shipment 2 onward.
Nothing is added at checkout except the USPS shipping you choose; dispatch and delivery are the same on every order. The cost-per-milligram tool ranks the whole catalog by price per mg.
Where to buy CJC-1295 with DAC: what to check before you order from anyone
Where to get CJC-1295 with DAC, and how to buy CJC-1295 with DAC online
You can buy CJC-1295 with DAC online here with guest checkout; verified in-stock orders placed before 12 PM Pacific are dispatched the same day.
Before ordering CJC-1295 with DAC from anyone, us included, run the 5 checks on verifying a certificate; the first is that the report resolves on the laboratory's own site, and a seller who cannot pass them is asking for the trust a certificate exists to replace.
CJC-1295 with DAC guides and documentation
Written to answer the questions that come up around CJC-1295 with DAC specifically, what its paperwork should show, how it is handled, and how to judge a supplier selling it.
The full library, grouped by what you came to answer, is in the laboratory guides.
The CJC-1295 with DAC certificate: lot, purity, identity, and how to verify it
A certificate answers identity, purity and net content as three separate questions, each with the method that produced it and the date it was run, how to read one covers what each field does and does not cover. For CJC-1295 with DAC that means a mass spectrum landing on 3,647.2 g/mol for C165H269N47O46, the figure published against PubChem CID 91971820.
CJC-1295 (with DAC) certificates post here and in the certificate index when Kovera Labs reports on the lot.
Solution arithmetic for the bench, with no administration guidance: the vial concentration calculator, preset to CJC-1295 (with DAC).
CJC-1295 with DAC research: what the published studies examine
Status: No FDA-approved application. This compound is sold as laboratory material. Where research on it has been published, it sits at the animal, cell or early-human stage, and this record does not summarize what it found. A supplier is not a neutral judge of evidence about its own catalog.
This is the molecule the published CJC-1295 literature actually describes, and it is worth being explicit that it is a different product from the no-DAC version also sold on this catalog. CJC-1295 is a tetrasubstituted form of hGRF(1-29) with an added N-epsilon-3-maleimidopropionamide derivative of lysine at the C-terminus. The four substitutions confer resistance to dipeptidyl peptidase-4; the maleimide is the part that matters most, reacting covalently with the free thiol at Cys34 of serum albumin so the peptide circulates bound to a carrier protein with a multi-day residence.
It binds the GHRH receptor on pituitary somatotrophs, acting upstream of growth hormone rather than supplying it.
| Reported observation | Model | Source |
|---|---|---|
| Identified as the best of three maleimido hGRF(1-29) derivatives, characterized as tetrasubstituted hGRF(1-29) with an added maleimidopropionamide lysine at the C terminus. All three conjugates showed enhanced in vitro stability against dipeptidylpeptidase-IV. Western blot of plasma from injected rats showed the compound on the band corresponding to serum albumin from 15 minutes and remaining beyond 24 hours, with the compound detectable past 72 hours. | in vitro DPP-IV stability, cultured rat anterior pituitary cells, rat pharmacokinetics | Jette and colleagues, Human growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: identification of CJC-1295 as a long-lasting GRF analog, Endocrinology (2005)Authored at ConjuChem, the developing company. |
| In two randomised placebo-controlled ascending-dose trials, single subcutaneous injections produced dose-dependent increases in mean plasma growth hormone of two- to ten-fold sustained for six days or more, and IGF-1 increases of 1.5- to 3-fold for nine to eleven days, with an estimated half-life of 5.8 to 8.1 days. After multiple doses IGF-1 remained above baseline for up to 28 days. No serious adverse reactions were reported. | randomised, placebo-controlled, double-blind ascending-dose trials in healthy adults aged 21 to 61 | Teichman and colleagues, Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, Journal of Clinical Endocrinology and Metabolism (2005) |
| In GHRH knockout mice, once-daily administration maintained normal body weight and length; every 48 or 72 hours produced partial but incomplete normalization. Total pituitary RNA and growth hormone mRNA rose and immunohistochemistry supported proliferation of somatotroph cells, indicating the effect is not simply release of stored hormone. | GHRH knockout mice, five weeks from one week of age | Alba and colleagues, Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse, American Journal of Physiology: Endocrinology and Metabolism (2006)Johns Hopkins, independent of the originating company. |
Open questions. The evidence base here is genuinely better than for most of this catalog: a defined mechanism, an independent knockout-mouse study, and two randomised human trials with pharmacokinetics. Three things still need saying. Development stopped, so there is no approved product, no pharmacopeial standard and no long-term safety record — and a compound that reached randomised human trials and went no further has been tested more than most things sold here without producing a licensed medicine.
Sustained elevation of growth hormone and IGF-1 over days to weeks is a real departure from the pulsatile physiological pattern, and whether that is desirable is an open question rather than a selling point. And the somatotroph proliferation reported in knockout mice is a structural change in the pituitary, not merely a secretory one.
Each row above describes an observation in the stated model. None of it describes what CJC-1295 (with DAC) would do in a person or an animal outside that model, and none of it is a recommendation to use it for anything.
How to store CJC-1295 with DAC: refrigeration and shelf life
Keep the sealed vial cold and out of the light and it stays as it left the lab. Once it is mixed into a solution, how long it holds up depends on the compound, what it was mixed with, how strong the solution is and how cold it is kept — too many variables for anyone to print one shelf life on a label. So laboratories write the date on whatever they prepare and keep their own record of it.
For solution preparation arithmetic on the bench, concentration, per-graduation values and molarity, use the vial concentration calculator, which opens with the CJC-1295 (with DAC) sizes stocked here already loaded. It covers laboratory measurement only and contains no administration guidance.
