Gonadorelin is synthetic gonadotropin-releasing hormone — the native decapeptide, identical in sequence to endogenous GnRH (formula C57H79N17O15, average mass 1,242.3 g/mol, CAS 52699-48-6). Gonadorelin Acetate is sold here for laboratory research in 1 size (2mg), from $55.00 a vial. It is not an FDA-approved medicine. Research use only, and never for people or animals.
Gonadorelin specifications
| Product name | Gonadorelin Acetate |
|---|---|
| Also sold as | Gonadorelin Acetate, Gonadorelin peptide, GnRH (gonadorelin) |
| Formula | C57H79N17O15 |
| Average mass | 1,242.3 g/mol |
| CAS number | 52699-48-6 |
| Physical form | Freeze-dried powder, a solid cake in a sealed vial |
| Appearance | White to off-white cake |
| Sizes on this page | 2mg |
| Purity specification | ≥99% by RP-HPLC. The number for the lot you receive is whatever its own certificate says. |
| Identity check | Mass spectrometry, read against the mass this compound should have |
| Net content | Weighed per lot and reported separately from purity |
| Lot documentation | Tested by Kovera Labs; each lot's certificate posts here when it is reported |
| Storage | Sealed, cold and out of the light |
| Ships from | Santa Ana, California by USPS with tracking on every order, same business day on verified in-stock orders placed before 12 PM Pacific |
| Intended use | Laboratory research only. Not for human or animal use. |
What is Gonadorelin, and what is it used for?
Gonadorelin is also listed and searched as Gonadorelin Acetate, Gonadorelin peptide, GnRH (gonadorelin). They all mean the same compound. Supplier lists write it as Gonadorelin peptides or peptide Gonadorelin as well; every one of those is this record. A name is not a test, which is why the lot record further down counts for more than the wording on a label.
Chemically: molecular formula C57H79N17O15, average mass 1242.3 g/mol (PubChem CID 11980076). Those figures are what the identity test on a certificate is read against.
Synthetic gonadotropin-releasing hormone — the native decapeptide, identical in sequence to endogenous GnRH.
Agonist at the GnRH receptor on pituitary gonadotrophs, stimulating release of luteinising hormone and follicle-stimulating hormone. The critical property is that the response depends on PULSATILE exposure: continuous stimulation desensitises the receptor and suppresses gonadotropin release rather than increasing it.
Diagnostic assessment of pituitary gonadotroph function, and reproductive endocrinology. The native peptide has a very short half-life; the therapeutically used GnRH analogues are modified for stability and deliberately exploit the desensitisation effect.
Nothing about sustained administration producing sustained gonadotropin release — the pharmacology says the opposite, and this is the most commonly misunderstood point about the compound.
Gonadorelin for sale: 2mg vials, price per mg
Gonadorelin is sold in 1 size here, 2mg, from $55.00 a vial. Gonadorelin cost and Gonadorelin price per mg by size are in the table, at each volume tier and on subscription; the per-mg figure under each price is the one that compares across sizes.
Volume and subscription pricing by size
| Size | One vial | 10–19 vials−10% | 20 vials−15% | Subscribe monthly−6% from shipment 2 | Availability |
|---|---|---|---|---|---|
| Gonadorelin 2mg | $55.00$27.50/mg | $49.50a vial · $24.75/mg | $46.75a vial · $23.38/mg | $51.70a vial, shipment 2 on · $25.85/mg | Backordered — waitlist |
Volume tiers are per size and do not combine across sizes (see bulk pricing). Subscribe & Save takes 6% every month, 4% every 2 months or 2% every 3 months off from shipment 2, two shipments minimum, and stacks on the volume tier: the lowest this record ever bills is $21.97 per mg, twenty 2mg vials on a monthly subscription from shipment 2 onward.
Nothing is added at checkout except the USPS shipping you choose; dispatch and delivery are the same on every order. The cost-per-milligram tool ranks the whole catalog by price per mg.
Where to buy Gonadorelin: what to check before you order from anyone
Where to get Gonadorelin, and how to buy Gonadorelin online
Gonadorelin for sale, or Gonadorelin peptide for sale, means this page: one record, 1 size. You can buy Gonadorelin online here with guest checkout; verified in-stock orders placed before 12 PM Pacific are dispatched the same day.
Before ordering Gonadorelin from anyone, us included, run the 5 checks on verifying a certificate; the first is that the report resolves on the laboratory's own site, and a seller who cannot pass them is asking for the trust a certificate exists to replace.
Gonadorelin capsules, nasal spray or oral form? What this vial is, and is not
Search results for Gonadorelin also show capsules, nasal spray, oral form products, under listing titles such as gonadorelin oral, gonadorelin nasal spray, gonadorelin pills, gonadorelin sublingual, gonadorelin tablet, gonadorelin tablets. Those are finished consumer goods made and marketed by other companies, and none of them is what this page sells. This record is freeze-dried Gonadorelin in a sealed glass vial, 2mg, with a lot certificate, supplied for laboratory work. Its certificate describes that powder, not a capsule, spray or cream, which carry other ingredients and sit under different rules.
Gonadorelin vs Kisspeptin-10: different molecules, separate records
Gonadorelin vs Kisspeptin-10, or Kisspeptin-10 vs Gonadorelin, is the comparison people search most, and they are not the same thing. Each is a different molecule with a different formula, mass and research record, and each has its own certificate here.
Kisspeptin-10 vs Gonadorelin: the same comparison, side by side
| Record | Class | Formula | Avg. mass | Sizes here |
|---|---|---|---|---|
| Gonadorelin Acetate | Synthetic gonadotropin-releasing hormone — the native decapeptide, identical in sequence to endogenous GnRH. | C57H79N17O15 | 1242.3 | 2mg from $55.00 |
| Kisspeptin-10 | A man-made peptide ten building blocks long, the tail end of kisspeptin. | C63H83N17O14 | 1302.4 | 5mg · 10mg from $60.00 |
Documentation compared in full: Gonadorelin vs Kisspeptin-10, side by side.
The Gonadorelin certificate: lot, purity, identity, and how to verify it
A certificate answers identity, purity and net content as three separate questions, each with the method that produced it and the date it was run, how to read one covers what each field does and does not cover. For Gonadorelin that means a mass spectrum landing on 1,242.3 g/mol for C57H79N17O15, the figure published against PubChem CID 11980076.
Listings elsewhere describe Gonadorelin Acetate as an acetate, an arginate salt or an N-acetyl form. Those are different chemical forms with different masses, and a certificate identifies which one was actually tested. The form of the lot on this page is whatever its certificate states; it is not assumed from a listing name, ours included.
Gonadorelin Acetate certificates post here and in the certificate index when Kovera Labs reports on the lot.
Where the FDA stands on Gonadorelin
FDA status, and what this listing is Not an FDA-approved drug product
The FDA has not approved this compound for anything, and nothing in this catalog is a medicine.
Status verified 2026-08-25. Check the primary source before relying on this summary.
It is sold as laboratory material under the research-use restriction below. Being listed is not an approval, and not a claim that it is safe, effective or right for any purpose.
Gonadorelin research: what the published studies examine
Status: No FDA-approved application. This compound is sold as laboratory material. Where research on it has been published, it sits at the animal, cell or early-human stage, and this record does not summarize what it found. A supplier is not a neutral judge of evidence about its own catalog.
Gonadorelin is native GnRH, the decapeptide the hypothalamus releases in pulses to drive pituitary gonadotropin secretion. The single most important thing about it is that the direction of its effect depends on the pattern of exposure, not just the amount. Pulsatile stimulation of the GnRH receptor drives LH and FSH release; CONTINUOUS stimulation desensitises the receptor and suppresses release.
This is not a subtle pharmacological footnote — it is the basis of an entire class of medicines, since the long-acting GnRH agonists used clinically work by deliberately causing that desensitisation to shut the axis down. So a compound whose native function is to stimulate the reproductive axis becomes, under continuous exposure, a suppressor of it. Anyone reasoning about this compound from its receptor identity alone, without accounting for exposure pattern, will predict the wrong sign.
| Reported observation | Model | Source |
|---|---|---|
| The kisspeptin literature establishes the position of GnRH in this axis directly: KISS1R is expressed on GnRH neurons, and central administration of kisspeptin in sheep produced measurable GnRH release into cerebrospinal fluid with a parallel rise in serum LH. GnRH neurons in GPR54 knockout mice were anatomically normal with intact median eminence projections, establishing that hypogonadism in those animals reflects failure of GnRH release rather than absent neurons. | mouse hypothalamus, GPR54 knockout mice, and direct GnRH measurement in sheep | Messager and colleagues, Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54, Proceedings of the National Academy of Sciences (2005)Cited for the GnRH-to-LH relationship it measures directly, one step downstream of where this compound acts. |
| A review of the KISS1/GPR54 system describes the hypothalamic gatekeeper role upstream of GnRH neurons, their activation at puberty and their regulation by gonadal steroids and probably metabolic factors — establishing the feedback-regulated context in which exogenous GnRH acts. | review of human genetics, animal and species-comparative work | Tena-Sempere, GPR54 and kisspeptin in reproduction, Human Reproduction Update (2006) |
Open questions. The pharmacology is well established and the practical warning follows from it rather than from any uncertainty: continuous GnRH receptor stimulation suppresses the reproductive axis rather than stimulating it, which is the opposite of what the receptor identity naively suggests and is exactly how the clinical GnRH agonists achieve their effect. Native gonadorelin also has a very short half-life, which is why the clinically used analogues are all modified. Two further points.
The reproductive axis is under steroid feedback control, so exogenous input produces different results depending on the endocrine state it enters. And a decapeptide is a straightforward synthesis, but sequence identity to native GnRH means an identity assay is the whole of what can be verified — there is no proprietary modification to confirm.
Each row above describes an observation in the stated model. None of it describes what Gonadorelin Acetate would do in a person or an animal outside that model, and none of it is a recommendation to use it for anything.
How to store Gonadorelin: refrigeration and shelf life
Keep the sealed vial cold and out of the light and it stays as it left the lab. Once it is mixed into a solution, how long it holds up depends on the compound, what it was mixed with, how strong the solution is and how cold it is kept — too many variables for anyone to print one shelf life on a label. So laboratories write the date on whatever they prepare and keep their own record of it.
For solution preparation arithmetic on the bench, concentration, per-graduation values and molarity, use the vial concentration calculator, which opens with the Gonadorelin Acetate sizes stocked here already loaded. It covers laboratory measurement only and contains no administration guidance.
