This page compares what is documented about Retatrutide and Semaglutide, rather than ranking them by effect. What each molecule is, the sizes and prices actually carried, what the certificate covers, and how the two differ on the bench. Everything here is research-use-only material and we do not publish outcome, dosing or administration content for any compound in the catalogue.
What is Retatrutide and what is Semaglutide?
Retatrutide. Retatrutide is a triple GIP/GLP-1/glucagon receptor agonist, and peer-reviewed metabolic-research output on multi-receptor incretin pharmacology has grown every year since 2022.
Semaglutide. Semaglutide is the most-cited GLP-1 receptor agonist in the research literature, which makes verified reference material a staple for comparative receptor work.
How do Retatrutide and Semaglutide compare on price and size?
| Retatrutide | Semaglutide | |
|---|---|---|
| Sizes carried | 5 mg, 10 mg, 15 mg, 20 mg, 30 mg, 40 mg, 50 mg, 60 mg | 5 mg, 10 mg, 15 mg, 20 mg, 30 mg |
| From | $80.00 | $80.00 |
| Best price per unit | $3.57 / mg | $3.83 / mg |
| Availability | Backordered — waitlist | Backordered — waitlist |
| Certificate | Lot certificate on the product page | Lot certificate on the product page |
| Molecular formula | C221H342N46O68 | C187H291N45O59 |
| Molar mass | 4,731.3 g/mol | 4,114 g/mol |
| Source | — | PubChem CID 56843331 |
| Research area | incretin receptor pharmacology | GLP-1 receptor research |
At their best sizes Retatrutide works out at $3.57 per mg against $3.83 for Semaglutide — 7% more for the mg. Vial prices start at $80.00 and $80.00 respectively, which is the number most people compare and the one that says least, because the two are not sold in the same sizes. Full sizes, tier pricing and the lot certificate sit on the Retatrutide page and the Semaglutide page.
What is each one studied for?
What the published literature investigates, which is a different question from what either will do, and the only one of the two a supplier can answer.
Retatrutide is studied in incretin receptor pharmacology research. Incretin pharmacology remains one of the most active areas in metabolic research, with multi-receptor agonists drawing sustained attention in the primary literature.
Semaglutide is studied in glp-1 receptor research. GLP-1 receptor biology continues to dominate metabolic-research publishing, and semaglutide remains its most-cited reference compound.
Studied in the same area does not make two compounds interchangeable, and the research library holds the per-compound documentation.
Semaglutide vs Retatrutide: how they differ on the bench
Semaglutide. Semaglutide degrades along predictable routes — our stability guide maps which storage regime suits sealed powder versus a working solution.
Retatrutide. Lyophilised retatrutide holds longest sealed, desiccated and dark; our storage guide covers why every degradation route accelerates the moment water enters the vial.
What actually differs between Semaglutide and Retatrutide
Worth doing the arithmetic before comparing sizes: Retatrutide is 4,731.3 g/mol and Semaglutide is 4,114 g/mol, a factor of 1.2. A milligram of Semaglutide therefore contains roughly 1.2 times as many molecules as a milligram of Retatrutide, so two vials of the same labelled mass hold quite different amounts of substance. Equal milligrams are not equal moles, which is what the molarity calculator exists to convert, and it is the reason a price-per-milligram comparison and a price-per-mole comparison can point at different vials.
Identity is the other analytical axis, and it is settled per lot rather than per compound. Semaglutide. Catalogued as Semaglutide, and the certificate's identity test resolves to that.
Both are released against a certificate reporting identity, purity by the stated method and net peptide content, readable before anything is bought.
Which is better, Semaglutide or Retatrutide?
Neither Semaglutide nor Retatrutide is ranked against the other here, and the refusal is deliberate. Better, safer and stronger are questions about effects in a living system, and we sell neither compound for use in one — why none of these pages ranks two compounds sets out the reasoning in full.
What it does instead, for these two:
- Retatrutide is the cheaper of the two per mg, at $3.57 against $3.83.
- Retatrutide is the heavier molecule by a factor of 1.2, so equal milligrams are not equal moles.
- Retatrutide is carried in 8 sizes and Semaglutide in 5, and each lot carries its own certificate.
Every one of those is checkable before you buy.
Common questions
What is the difference between Semaglutide and Retatrutide?
Different molecules before anything else: Semaglutide is C187H291N45O59 and Retatrutide is C221H342N46O68. Semaglutide is the most-cited GLP-1 receptor agonist in the research literature, which makes verified reference material a staple for comparative receptor work. Retatrutide is a triple GIP/GLP-1/glucagon receptor agonist, and peer-reviewed metabolic-research output on multi-receptor incretin pharmacology has grown every year since 2022.
Which one should I choose?
Retatrutide is carried in 5 mg, 10 mg, 15 mg, 20 mg, 30 mg, 40 mg, 50 mg, 60 mg and Semaglutide in 5 mg, 10 mg, 15 mg, 20 mg, 30 mg, each lot with its own certificate. Which of those suits the work is yours to decide; everything here is research-use-only rather than guidance for use in a human or an animal.
Do both Retatrutide and Semaglutide come with a certificate of analysis?
Neither is in stock at the moment, so in each case the certificate is the one attached to the lot that arrives. A certificate belongs to a lot, not to a product. It is linked from the product page, and reports identity, purity by the stated method, and net peptide content for the material actually in that lot.
Which is cheaper, Semaglutide or Retatrutide?
Per mg, Retatrutide at $3.57 against $3.83, taking each one's best size. By vial they start at $80.00 for Retatrutide and $80.00 for Semaglutide, which is the comparison most people make and the one that says least, because the two are not sold in the same sizes.
Is a milligram of Retatrutide the same as a milligram of Semaglutide?
By mass yes, by amount of substance no. Retatrutide is 4,731.3 g/mol and Semaglutide is 4,114 g/mol, a factor of 1.2, so a milligram of Semaglutide holds roughly 1.2 times as many molecules. Two vials with the same number on the label are not the same amount of substance, which is what the molarity calculator converts.
FOR LABORATORY AND IN-VITRO RESEARCH USE ONLY. NOT FOR HUMAN OR ANIMAL CONSUMPTION. NOT FOR PERSONAL, MEDICAL, DIAGNOSTIC, THERAPEUTIC, OR RECREATIONAL USE.