VIP is vasoactive intestinal peptide — a 28-residue endogenous peptide hormone in the secretin/glucagon superfamily (formula C147H237N43O43S, average mass 3,326.8 g/mol, CAS 37221-79-7). VIP is sold here for laboratory research in 2 sizes (5mg to 10mg), from $65.00 a vial. It is not an FDA-approved medicine. Research use only, and never for people or animals.
VIP specifications
| Product name | VIP |
|---|---|
| Also sold as | vasoactive intestinal peptide, VIP peptide |
| Formula | C147H237N43O43S |
| Average mass | 3,326.8 g/mol |
| CAS number | 37221-79-7 |
| Physical form | Freeze-dried powder, a solid cake in a sealed vial |
| Appearance | White to off-white cake |
| Sizes on this page | 5mg · 10mg |
| Purity specification | ≥99% by RP-HPLC. The number for the lot you receive is whatever its own certificate says. |
| Identity check | Mass spectrometry, read against the mass this compound should have |
| Net content | Weighed per lot and reported separately from purity |
| Lot documentation | Tested by Kovera Labs; each lot's certificate posts here when it is reported |
| Storage | Sealed, cold and out of the light |
| Ships from | Santa Ana, California by USPS with tracking on every order, same business day on verified in-stock orders placed before 12 PM Pacific |
| Regulatory status | Not an FDA-approved drug product. Sold as laboratory material, not a medicine; status verified 2026-08-25. |
| Intended use | Laboratory research only. Not for human or animal use. |
What is VIP, and what is it used for?
VIP is also listed and searched as vasoactive intestinal peptide, VIP peptide. They all mean the same compound. Supplier lists write it as VIP peptides or peptide VIP as well; every one of those is this record. A name is not a test, which is why the lot record further down counts for more than the wording on a label.
Chemically: molecular formula C147H237N43O43S, average mass 3326.8 g/mol (PubChem CID 53314964). Those figures are what the identity test on a certificate is read against.
Vasoactive intestinal peptide — a 28-residue endogenous peptide hormone in the secretin/glucagon superfamily.
Agonist at the VPAC1 and VPAC2 class B G-protein-coupled receptors, both of which respond to VIP and to the related peptide PACAP with high affinity. It does not activate the PAC1 receptor, which is PACAP-selective.
Circadian rhythm, learning and memory, anxiety and stress responses in the central nervous system; control of immunity and inflammation, pancreatic insulin secretion and adrenal catecholamine release in the periphery. A large mainstream physiology literature.
No approved VIP product. Its extremely short circulating half-life is the practical obstacle that has defeated development repeatedly.
VIP for sale: 5mg and 10mg vials, price per mg
VIP is sold in 2 sizes here, 5mg and 10mg, from $65.00 a vial. Every way of buying is in the table; the per-mg figure under each price is the one that compares across sizes.
Volume and subscription pricing by size
| Size | One vial | 10–19 vials−10% | 20 vials−15% | Subscribe monthly−6% from shipment 2 | Availability |
|---|---|---|---|---|---|
| VIP 5mg | $65.00$13.00/mg | $58.50a vial · $11.70/mg | $55.25a vial · $11.05/mg | $61.10a vial, shipment 2 on · $12.22/mg | Backordered — waitlist |
| VIP 10mg | $150.00$15.00/mg | $135.00a vial · $13.50/mg | $127.50a vial · $12.75/mg | $141.00a vial, shipment 2 on · $14.10/mg | Backordered — waitlist |
Volume tiers are per size and do not combine across sizes (see bulk pricing). Subscribe & Save takes 6% every month, 4% every 2 months or 2% every 3 months off from shipment 2, two shipments minimum, and stacks on the volume tier: the lowest this record ever bills is $10.39 per mg, twenty 5mg vials on a monthly subscription from shipment 2 onward.
Nothing is added at checkout except the USPS shipping you choose; dispatch and delivery are the same on every order. The cost-per-milligram tool ranks the whole catalog by price per mg.
Where to buy VIP: what to check before you order from anyone
Where to get VIP, and how to buy VIP online
VIP for sale, or VIP peptide for sale, means this page: one record, 2 sizes. You can buy VIP online here with guest checkout; verified in-stock orders placed before 12 PM Pacific are dispatched the same day.
Before ordering VIP from anyone, us included, run the 5 checks on verifying a certificate; the first is that the report resolves on the laboratory's own site, and a seller who cannot pass them is asking for the trust a certificate exists to replace.
VIP nasal spray? What this vial is, and is not
Search results for VIP also show nasal spray products, under listing titles such as vip peptide nasal spray, vasoactive intestinal peptide vip nasal spray. Those are finished consumer goods made and marketed by other companies, and none of them is what this page sells. This record is freeze-dried VIP in a sealed glass vial, 5mg and 10mg, with a lot certificate, supplied for laboratory work. Its certificate describes that powder, not a capsule, spray or cream, which carry other ingredients and sit under different rules.
The VIP certificate: lot, purity, identity, and how to verify it
A certificate answers identity, purity and net content as three separate questions, each with the method that produced it and the date it was run, how to read one covers what each field does and does not cover. For VIP that means a mass spectrum landing on 3,326.8 g/mol for C147H237N43O43S, the figure published against PubChem CID 53314964.
VIP certificates post here and in the certificate index when Kovera Labs reports on the lot.
Solution arithmetic for the bench, with no administration guidance: the vial concentration calculator, preset to VIP.
VIP research: what the published studies examine
Status: No FDA-approved application. This compound is sold as laboratory material. Where research on it has been published, it sits at the animal, cell or early-human stage, and this record does not summarize what it found. A supplier is not a neutral judge of evidence about its own catalog.
VIP belongs to a structurally related superfamily that includes glucagon, the glucagon-like peptides, secretin, GIP and GHRH — which is worth noting on this catalog, because several of those relatives appear here as separate products and the family resemblance is real rather than nominal. VIP and the related peptide PACAP act through three class B GPCRs: PAC1, which is PACAP-selective, and VPAC1 and VPAC2, which respond to both with high affinity. The functional range is unusually wide.
Centrally, VIP is involved in circadian rhythm control, learning and memory, anxiety and responses to stress and brain injury. Peripherally it participates in immunity and inflammation, pancreatic insulin secretion, adrenal catecholamine release, and acts as a co-transmitter in autonomic and sensory neurons. Genetic work has implicated the VPAC2 receptor in susceptibility to schizophrenia, which gives some sense of how central this system is.
| Reported observation | Model | Source |
|---|---|---|
| The IUPHAR review confirming receptor nomenclature: VIP and PACAP act through PAC1, VPAC1 and VPAC2, class B GPCRs; PAC1 is PACAP-selective while VPAC1 and VPAC2 respond to both with high affinity. Functions span circadian rhythms, learning and memory, anxiety and stress responses centrally, and immunity, inflammation, pancreatic insulin secretion, adrenal catecholamine release and autonomic co-transmission peripherally. VPAC2 has been implicated in schizophrenia susceptibility and PAC1 in post-traumatic stress disorder. | IUPHAR receptor nomenclature and pharmacology review | Harmar and colleagues, Pharmacology and functions of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide: IUPHAR review 1, British Journal of Pharmacology (2012)The official IUPHAR nomenclature review — as authoritative as receptor pharmacology sources get. |
Open questions. The receptor pharmacology here is about as well established as anything on this catalog, being the subject of an official IUPHAR nomenclature review. The problems are practical. VIP has a very short circulating half-life, which is the reason repeated development efforts have not produced an approved product despite decades of interest and a compelling biology.
Its receptors are expressed across an extremely wide range of tissues and functions — circadian, cognitive, immune, pancreatic, autonomic — which means systemic exposure is systemic in an unusually literal sense, and selectivity for any one of those effects is not achievable with the native peptide. VPAC1 and VPAC2 also cannot be distinguished by VIP itself, since it binds both with high affinity, so the peptide is a blunt tool for asking which receptor does what.
Each row above describes an observation in the stated model. None of it describes what VIP would do in a person or an animal outside that model, and none of it is a recommendation to use it for anything.
How to store VIP: refrigeration and shelf life
Keep the sealed vial cold and out of the light and it stays as it left the lab. Once it is mixed into a solution, how long it holds up depends on the compound, what it was mixed with, how strong the solution is and how cold it is kept — too many variables for anyone to print one shelf life on a label. So laboratories write the date on whatever they prepare and keep their own record of it.
For solution preparation arithmetic on the bench, concentration, per-graduation values and molarity, use the vial concentration calculator, which opens with the VIP sizes stocked here already loaded. It covers laboratory measurement only and contains no administration guidance.
